Identifying Genetic Signatures Associated with Oncogene-Induced Replication Stress in Osteosarcoma and Screening for Potential Targeted Drugs

Comprehensive analysis of the clinical significance and molecular mechanism of T-box transcription factor 3 in osteosarcoma

“…Notably, exisulind, a small-molecule medication, exhibited outstanding potential for targeted therapy for TBX3 in primary OS samples (Figure 6 A-B). We believe that tacrolimus is more likely to target TBX3 in cases with OS metastasis (Figure 6 C-D) and the 2D structure and PK/PD parameters of exisulind & tacrolimus are shown in Supplementary Table 2 and Supplementary Table 3 40 .…”