Identifying exposure pathways mediating adverse birth outcomes near active surface mines in Central Appalachia

Ruktanonchai, Corrine W.; McKnight, Molly Xi; Marr, Linsey C.; Kolivras, Korine N.; Krometis, Leigh‐Anne; Gohlke, Julia M.

doi:10.1097/ee9.0000000000000208

Cited by 4 publications

(2 citation statements)

References 39 publications

(64 reference statements)

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“…To allow for secular, nonlinear trends in birth outcomes, we used the splines package in R software, incorporating inflection points (or splines) where fixed effects could vary [ 38 ]. Similar approaches have been utilized to characterize associations between birth outcomes and other environmental exposures [ 39 , 40 , 41 ].…”

Section: Methodsmentioning

confidence: 99%

Poultry Concentrated Animal-Feeding Operations on the Eastern Shore, Virginia, and Geospatial Associations with Adverse Birth Outcomes

et al. 2022

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Concentrated animal-feeding operations (CAFOs) emit pollution into surrounding areas, and previous research has found associations with poor health outcomes. The objective of this study was to investigate if home proximity to poultry CAFOs during pregnancy is associated with adverse birth outcomes, including preterm birth (PTB) and low birth weight (LBW). This study includes births occurring on the Eastern Shore, Virginia, from 2002 to 2015 (N = 5768). A buffer model considering CAFOs within 1 km, 2 km, and 5 km of the maternal residence and an inverse distance weighted (IDW) approach were used to estimate proximity to CAFOs. Associations between proximity to poultry CAFOs and adverse birth outcomes were determined by using regression models, adjusting for available covariates. We found a −52.8 g (−95.8, −9.8) change in birthweight and a −1.51 (−2.78, −0.25) change in gestational days for the highest tertile of inverse distance to CAFOs. Infants born with a maternal residence with at least one CAFO within a 5 km buffer weighed −47 g (−94.1, −1.7) less than infants with no CAFOs within a 5 km buffer of the maternal address. More specific measures of exposure pathways via air and water should be used in future studies to refine mediators of the association found in the present study.

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Section: Methodsmentioning

confidence: 99%

Poultry Concentrated Animal-Feeding Operations on the Eastern Shore, Virginia, and Geospatial Associations with Adverse Birth Outcomes

et al. 2022

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“…Exposure period was classified via majority gestational year (MGY). Birth records were assigned to the year in which the majority of gestation occurred using gestational age and birth date to determine the midpoint of the gestational period [50,51]. For example, a birth that occurs in February would be matched with contaminant occurrence data in the previous year when most exposure during pregnancy would have occurred, rather than the year in which the birth occurred.…”

Section: Data Processingmentioning

confidence: 99%

Unregulated drinking water contaminants and adverse birth outcomes in Virginia

Young,

Kolivras,

Krometis

et al. 2024

PLOS Water

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Through the Unregulated Contaminant Monitoring Rule (UCMR), the Environmental Protection Agency monitors selected unregulated drinking water contaminants of potential concern. While contaminants listed in the UCMR are monitored, they do not have associated health-based standards, so no action is required following detection. Given evolving understanding of incidence and the lack of numeric standards, previous examinations of health implications of drinking water generally only assess impacts of regulated contaminants. Little research has examined associations between unregulated contaminants and fetal health. This study individually assesses whether drinking water contaminants monitored under UCMR 2 and, with a separate analysis, UCMR 3, which occurred during the monitoring years 2008–2010 and 2013–2015 respectively, are associated with fetal health outcomes, including low birth weight (LBW), term-low birth weight (tLBW), and preterm birth (PTB) in Virginia. Singleton births (n = 435,449) that occurred in Virginia during UCMR 2 and UCMR 3 were assigned to corresponding estimated water service areas (n = 435,449). Contaminant occurrence data were acquired from the National Contaminant Occurrence Database, with exposure defined at the estimated service area level to limit exposure misclassification. Logistic regression models for each birth outcome assessed potential associations with unregulated drinking water contaminants. Within UCMR 2, N-Nitroso-dimethylamine was positively associated with PTB (OR = 1.08; 95% CI: 1.02, 1.14, P = 0.01). Molybdenum (OR = 0.92; 95% CI: 0.87, 0.97, P = 0.0) and vanadium (OR = 0.96; 95% CI: 0.92, 1.00, P = 0.04), monitored under UCMR 3, were negatively associated with LBW. Molybdenum was also negatively associated (OR = 0.90; 95% CI: 0.82, 0.99, P = 0.03) with tLBW, though chlorodifluoromethane (HCFC-22) was positively associated (OR 1.18; 95% CI: 1.01, 1.37, P = 0.03) with tLBW. These findings indicate that unregulated drinking water contaminants may pose risks to fetal health and demonstrate the potential to link existing health data with monitoring data when considering drinking water regulatory determinations at the national scale.

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Examining the association between safe drinking water act violations and adverse birth outcomes in Virginia

Young

Kolivras

Krometis

et al. 2023

Environmental Research

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Identifying exposure pathways mediating adverse birth outcomes near active surface mines in Central Appalachia

Abstract: R21ES028396). Data use agreements with state health agencies prohibit authors from sharing birth record data used in the analysis. Satellite-derived datasets are publicly available, or available on request. Code required to replicate results are available upon request.

Cited by 4 publications

References 39 publications

Poultry Concentrated Animal-Feeding Operations on the Eastern Shore, Virginia, and Geospatial Associations with Adverse Birth Outcomes

Poultry Concentrated Animal-Feeding Operations on the Eastern Shore, Virginia, and Geospatial Associations with Adverse Birth Outcomes

Unregulated drinking water contaminants and adverse birth outcomes in Virginia

Examining the association between safe drinking water act violations and adverse birth outcomes in Virginia

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