Identifying Compound Effect of Drugs on Rheumatoid Arthritis Treatment Based on the Association Rule and a Random Walking-Based Model

Fang, Yanyan; Liu, Jian; Xin, Ling; Sun, Yue; Wan, Lei; Huang, Dan; Wen, Jianting; Zhang, Ying; Wang, Bing

doi:10.1155/2020/4031015

Cited by 14 publications

(14 citation statements)

References 19 publications

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“…Optimal administration of OA appeals for individual methods on the basis of various constitutions of human body. The individually integrated TCM approach in this research has been generated by clinical experience from the First Affiliated Hospital [ 19 ]. The approach comprises a fundamental treatment of orally administered Chinese herbal drugs and herbal patch on the basis of the severity of the patient symptoms.…”

Section: Discussionmentioning

confidence: 99%

Exploratory Compatibility Regularity of Traditional Chinese Medicine on Osteoarthritis Treatment: A Data Mining and Random Walk-Based Identification

Zhou

Liu

Xin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Osteoarthritis (OA) is a degressive and complex disease which is a growing public health problem on a global scale. On basis of an in-house database consisting of clinical records of 13,083 OA patients, the Traditional Chinese Medicine (TCM) was divided into 4 categories of medicines on the basis of the curative properties of herbs. Due to the lack of depth and internal relationship in the calculation results of TCM compatibility law data mining methods such as statistics and frequency analysis, we use a variety of multidimensional complex network methods that can efficaciously find the compatibility law of TCM, including similarity measure, graphical visualization of network diagram, random walking, and propensity score methods. We summarize common couplet medicines utilized for the treatment of osteoarthritis. The similarity measure method was used to investigate the commonly used drugs for the treatment of osteoarthritis. The method of association rule analysis is used to recognize the compatibility between the components. On basis of the propensity score methods, the evaluation displayed that, compared with single drug, the drug group increased ESR, CRP, C3, C4, IgG, and IgA more efficiently. Concluding, a random walk model was constructed to assess drug efficacy. After applying a random walk model, while revealing the compatibility among different components of TCM, their therapeutic efficacy against OA is analyzed. We obtained four groups of drug combination clusters by similarity measure and 11 pairs of highly connected drugs by association rules, which are cardinal drug combinations in the prescription for the treatment of OA. We also found that different traditional drug pairs were associated with different laboratory indexes, and drug combinations could better optimize laboratory indexes. This study presented that the TCM constituents complement one another. Besides, the therapeutic effects resulting from a variety of combinations of these constituents are quite different.

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Section: Discussionmentioning

confidence: 99%

Exploratory Compatibility Regularity of Traditional Chinese Medicine on Osteoarthritis Treatment: A Data Mining and Random Walk-Based Identification

Zhou

Liu

Xin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…The combined use of TCM is a common way to treat diseases, which often exerts the effect of increasing efficiency and reducing toxicity [ 33 ]. Multicomponents, multitargets, and multichannels are the characteristics of TCM in the treatment of RA and anemia [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine Is Associated with Reduced Risk of Readmission in Rheumatoid Arthritis Patients with Anemia: A Retrospective Cohort Study

Sun

Liu

Xin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. This study aimed to analyze the effect of traditional Chinese medicine (TCM) on the risk of readmission for rheumatoid arthritis (RA) patients with anemia. Methods. In this study, 893 hospitalized RA patients were followed up by telephone. A retrospective cohort study was conducted using propensity score matching (PSM). The Cox proportional hazards model was used to assess the influence of various factors on the risk of readmission for RA patients with anemia. The Kaplan–Meier survival curve was utilized to analyze the effect of TCM intervention time on readmission. Results. The incidence of anemia was 58.08% (471/811) in RA patients. After 1 : 1 PSM, 328 RA patients with anemia and 328 RA patients without anemia were finally included in our study. The readmission rate of anemia patients was higher than that of patients without anemia ( P < 0.01 ). The readmission rate of RA patients with anemia was obviously lower in the TCM group than in the non-TCM group ( P < 0.01 ). The Cox proportional hazards model showed TCM as an independent protective factor as it decreased the risk of readmission by 50% (HR = 0.50, 95% CI = 0.27–0.94, P = 0.03 ) in RA patients with anemia. In addition, the risk of readmission was dramatically diminished in the high-exposure subgroup (TCM > 12 months) compared with the low-exposure subgroup (TCM ≤ 12 months) (log-rank P = 0.016 ). Conclusion. TCM, as a protective factor, is associated with a reduced risk of readmission in RA patients with anemia.

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“…The formula of association rules was employed by referring to the published literature of Fang et al. 24 …”

Section: Methodsmentioning

confidence: 99%

“…Indicators, including ESR, CRP, RF, anti-CCP, IgA, IgG, IgM, complement component 3 (C3), C4, and a1-AGP, with increased levels were set as "T," whereas indicators with normal or reduced levels were set as "F." Indicators, including the RBC count, serum Fe, and serum Ca, with decreased levels were designated "T," whereas indicators with normal or elevated levels were set as "F." A length of hospital stay exceeding the median value (>16.95 days) was set as "T." Sharp score >28.25 was set as "T," whereas Sharp score 28.25 was designated "F." IBM SPSS modeler 18.0 software (IBM, Armonk, NY, USA) was used to analyze the correlation among observation indicators. The formula of association rules was employed by referring to the published literature of Fang et al 24…”

Section: Association Rule Analysismentioning

confidence: 99%

Factors influencing the Sharp score of 1057 patients with rheumatoid arthritis and anemia: a retrospective study

et al. 2022

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Objective This study examined the relationship of the Sharp score with demographic factors and clinical immune-inflammatory markers in patients with anemia in rheumatoid arthritis (RA). Methods The clinical data of 1057 patients with RA and anemia and 1006 patients with RA without anemia were retrospectively analyzed. Spearman’s correlation coefficient analysis, association rule analysis, and logistic regression were used to study the relationships between the Sharp score and influencing factors in patients with RA and anemia. Results The incidence of anemia was 51.24% (1057/2063), and mild anemia accounted for 81.93% (866/1057) of cases. Spearman’s correlation coefficient and association rule analyses revealed that the Sharp score of patients with RA and anemia was correlated with immune-inflammatory response and anemia. Logistic regression analysis illustrated that advanced age (>60 years), female, low serum iron levels, C-reactive protein positivity, and immunoglobulin A positivity were risk factors for a high Sharp score (>28.25) in patients with RA and anemia. Conclusion The Sharp score is closely related to clinical disease activity and anemia, and it should be considered in the treatment strategy of patients with RA and anemia.

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Identifying Compound Effect of Drugs on Rheumatoid Arthritis Treatment Based on the Association Rule and a Random Walking-Based Model

Cited by 14 publications

References 19 publications

Exploratory Compatibility Regularity of Traditional Chinese Medicine on Osteoarthritis Treatment: A Data Mining and Random Walk-Based Identification

Exploratory Compatibility Regularity of Traditional Chinese Medicine on Osteoarthritis Treatment: A Data Mining and Random Walk-Based Identification

Traditional Chinese Medicine Is Associated with Reduced Risk of Readmission in Rheumatoid Arthritis Patients with Anemia: A Retrospective Cohort Study

Factors influencing the Sharp score of 1057 patients with rheumatoid arthritis and anemia: a retrospective study

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