Abstract:RATIONALE: Striking class I HLA risk associations and CD8+ T cell dependency have been described for both Stevens-Johnson Syndrome/ toxic epidermal necrolysis (SJS/TEN) and abacavir hypersensitivity (AHS). However, distinct clinical phenotypes and positive predictive values (55% for HLA-B*57:01 restricted AHS and <8% for all HLA risk alleles and SJS/TEN) highlight key mechanistic differences. METHODS: Single cell technologies including T-cell receptor ab sequencing, multi-parameter flow cytometry, full transcr… Show more
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