Identifying, Assessing, and Treating Bipolar Disorder at School

Hart, Shelley R.; Brock, Stephen E.; Jeltova, Ida

doi:10.1007/978-1-4614-7585-9

Cited by 3 publications

(1 citation statement)

References 232 publications

(420 reference statements)

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“…More than a quarter of the children and adolescents with SJS/TEN with recorded indication for use received LTG for affective and behavioural disorders. LTG is however not licensed for these conditions in children and adolescents, 21 which means that these population of patients were treated without support from controlled randomised studies. Therefore, a careful risk–benefit assessment for the individual needs to be established before using LTG in this population.…”

Section: Discussionmentioning

confidence: 99%

Retrospective review of paediatric case reports of Stevens-Johnson syndrome and toxic epidermal necrolysis with lamotrigine from an international pharmacovigilance database

Egunsola

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Juhlin

et al. 2017

bmjpo

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ObjectivesThis study aims to characterise paediatric reports with lamotrigine (LTG) and Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN), and to explore whether potential risk factors can be identified.DesignThis is a retrospective review of suspected adverse drug reaction (ADR) reports. Reported time from LTG start to SJS/TEN onset, indication for use and dose was explored. To identify potential risk groups, report features (eg, ages, patient sex, co-reported drugs) for LTG and SJS/TEN were contrasted with two reference groups in the same database, using shrinkage logOR.SettingReports were retrieved from VigiBase, the WHO global database of individual case safety reports, in January 2015.PatientsData for patients aged ≤17 years old were extracted.ResultsThere were 486 reports of SJS/TEN in LTG-treated paediatric patients. Ninety-seven per cent of the cases with complete information on time to onset of SJS/TEN occurred within 8 weeks of initiation of LTG therapy. The median time to onset was 15 days (IQR: 10–22 days). The proportion of SJS/TEN with LTG and valproic acid (VPA) co-reporting was significantly more than non-cutaneous ADRs (43% vs 19%, (logOR: 1.60 (99% CI: 1.33 to 1.84)).ConclusionsThe results suggest that VPA co-medication with LTG therapy is a risk factor for SJS/TEN in the paediatric population. Although this relationship has been identified from individual case reports, this is the first supportive study from a large compilation of cases. SJS/TEN risk is highest in first 8 weeks of treatment with LTG in children and clinicians should be aware of this risk during this period.

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Section: Discussionmentioning

confidence: 99%

Retrospective review of paediatric case reports of Stevens-Johnson syndrome and toxic epidermal necrolysis with lamotrigine from an international pharmacovigilance database

Egunsola

Star

Juhlin

et al. 2017

bmjpo

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Towards best practice in school management of students with depressive disorders

Burns

2021

J. Psychol. Couns. Sch.

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There is growing evidence of an escalation of depression in young people. In light of this, schools are increasingly being confronted with the challenge of how to best manage students with depressive disorders. Such management includes consideration of the academic, behavioural, social and emotional implications of the disorder. This article provides school practitioners and management with a review of what constitutes ‘best practice’ in school management of students with depressive disorders. It adopts the mental health intervention framework of the Institute of Medicine, considering how school-based intervention occurs across the four domains of mental health promotion, prevention, case identification and treatment, as well as maintenance of students with or at-risk of depression. It provides a checklist for practitioners at each stage of the Institute of Medicine intervention spectrum. Moreover, it takes the view that best practice in psychology is always evidence-based practice, although discerning a clear path through the available research is not always obvious.

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