Background: Myofascial pain syndrome is collection of sensory, motor, and autonomic symptoms that include local and referred pain, decreased range of motion, and weakness. Objective: To compare outcome of physical therapy alone and physical therapy with trigger point injection in the management of myofascial pain syndrome. Materials and methods: This prospective randomized control study was performed in a tertiary-care teaching institution of North India. Ageand sex-matched subjects with myofascial pain syndrome were enrolled in this study. Subjects were assessed by cervical ROM parameters, numerical pain rating scale, and pressure pain threshold at third day, 1 week, and fourth week. Results: Sixty patients were included in this study with mean age-group of 25.93 + 4.65 years and 26.60 + 4.99 years, respectively, and median of 22 years and 23 years in control and intervention groups, respectively.