Identifying and quantifying load-dependence in transcription initiation by T7 RNA Polymerase

Abstract

demonstrates that a wide range of biological phenomena can be explained by interactions between TFs and chromatin, and provides a quantitative description of the following processes: cooperative binding and synergistic action of non-interacting TFs; access of TFs to chromatinized DNA; displacement of nucleosomes from regulatory regions; rapid evolutionary changes in arrangement and membership of TF-binding sites in eukaryotic regulatory regions.