Identifying an immune signature against invasive
            <i>Salmonella</i>

Ferreira, Rosana B. R.; Finlay, B. Brett

doi:10.1073/pnas.1201825109

Cited by 5 publications

(4 citation statements)

References 13 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, achieving cross protection among serotypes remains an elusive target [233,351]. However, perhaps a better strategy may be to use the host animal as a means to screen for immune signals that are common signatures to systemic infection of Salmonella in chickens as has been done recently in murine and human Salmonella systemic infections [352,353]. Improvements in design of Salmonella carrier vaccines are also emerging that induce greater immune responses by using regulated in vivo attenuation as well as regulated delayed in vivo antigen synthesis [323].…”

Section: Targeted Mutagenesis and Salmonella Carrier Vaccine Developmmentioning

confidence: 99%

Application of Molecular Approaches for Understanding Foodborne Salmonella Establishment in Poultry Production

Ricke

2014

Advances in Biology

View full text Add to dashboard Cite

Salmonellosis in the United States is one of the most costly foodborne diseases. Given thatSalmonellacan originate from a wide variety of environments, reduction of this organism at all stages of poultry production is critical.Salmonellaspecies can encounter various environmental stress conditions which can dramatically influence their survival and colonization. Current knowledge ofSalmonellaspecies metabolism and physiology in relation to colonization is traditionally based on studies conducted primarily with tissue culture and animal infection models. Consequently, while there is some information about environmental signals that controlSalmonellagrowth and colonization, much still remains unknown. Genetic tools for comprehensive functional genomic analysis ofSalmonellaoffer new opportunities for not only achieving a better understanding ofSalmonellapathogens but also designing more effective intervention strategies. Now the function(s) of each single gene in theSalmonellagenome can be directly assessed and previously unknown genetic factors that are required forSalmonellagrowth and survival in the poultry production cycle can be elucidated. In particular, delineating the host-pathogen relationships involvingSalmonellais becoming very helpful for identifying optimal targeted gene mutagenesis strategies to generate improved vaccine strains. This represents an opportunity for development of novel vaccine approaches for limitingSalmonellaestablishment in early phases of poultry production. In this review, an overview ofSalmonellaissues in poultry, a general description of functional genomic technologies, and their specific application to poultry vaccine developments are discussed.

show abstract

Section: Targeted Mutagenesis and Salmonella Carrier Vaccine Developmmentioning

confidence: 99%

Application of Molecular Approaches for Understanding Foodborne Salmonella Establishment in Poultry Production

Ricke

2014

Advances in Biology

View full text Add to dashboard Cite

show abstract

“…Protein microarray systems have been investigated as means for screening a large number of antigens to determine which antigen(s) an antibody will best recognize (most sensitive and specific; Lee et al, 2012;Yu et al, 2013). Also, a protein microarray can be used to determine the affinity of an antigen against a library of antibodies (Ferreira & Finlay, 2012;Rivas et al, 2008). These methods will potentially be useful in vaccine and cancer research (Yu et al, 2013), as well as in other areas where the affinity of a large number of antigens or antibodies needs to be characterized.…”

Section: Novel Clone Libraries and Systems Specific For Antibody Prodmentioning

confidence: 99%

Immuno-based detection of Shiga toxin-producing pathogenicEscherichia coliin food – A review on current approaches and potential strategies for optimization

Baker

Rubinelli

Park

et al. 2015

Critical Reviews in Microbiology

View full text Add to dashboard Cite

Certain pathogenic Escherichia coli known as Shiga toxin (Stx)-producing E. coli (STEC) are a public health threat to the consumer, and are problematic for the food industry. Food products containing STEC are deemed unfit for human consumption, and STEC illnesses can cause hemolytic uremic syndrome (HUS), a disease affecting the kidneys in susceptible individuals. Optimizing detection methods in foods have been focused on more prompt and accurate analysis. This review addresses the role and applications of immuno-based assays for STEC detection in food systems. Immunoassay antibody capture systems and flow cytometry platforms have been implemented into several food-based detection systems. By applying antibodies that will interact with target microorganisms, immunoassays can be used to directly detect and quantify pathogens. Immuno-based protocols could potentially be further implemented into the food industry, limit the duration of the detection process and increase accuracy.

show abstract

“…ducing costs to enable the high-throughput characterization of hundreds of genes in parallel. Similarly, the analysis of the antibody repertoire with antigen microarrays led to large-scale analyses of the immune response in autoimmune diseases (24 -27 ), allergies (28,29 ), response to tumors (30,31 ), vaccinations (32 ), and infections (33 ). These studies identified antibody signatures of clinical value ( Fig.…”

Section: Peptoidsmentioning

confidence: 99%

Antigen Microarrays for the Study of Autoimmune Diseases

Yeste

Quintana

2013

Clinical Chemistry

View full text Add to dashboard Cite

BACKGROUND The immune response involves the activation of heterogeneous populations of T cells and B cells that show different degrees of affinity and specificity for target antigens. Although several techniques have been developed to study the molecular pathways that control immunity, there is a need for high-throughput assays to monitor the specificity of the immune response. CONTENT Antigen microarrays provide a new tool to study the immune response. We reviewed the literature on antigen microarrays and their advantages and limitations, and we evaluated their use for the study of autoimmune diseases. Antigen arrays have been successfully used for several purposes in the investigation of autoimmune disorders: for disease diagnosis, to monitor disease progression and response to therapy, to discover mechanisms of pathogenesis, and to tailor antigen-specific therapies to the autoimmune response of individual patients. In this review we discuss the use of antigen microarrays for the study of 4 common autoimmune diseases and their animal models: type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis. CONCLUSIONS Antigen microarrays constitute a new tool for the investigation of the immune response in autoimmune disorders and also in other conditions such as tumors and allergies. Once current limitations are overcome, antigen microarrays have the potential to revolutionize the investigation and management of autoimmune diseases.

show abstract

Identifying an immune signature against invasive Salmonella

Cited by 5 publications

References 13 publications

Application of Molecular Approaches for Understanding Foodborne Salmonella Establishment in Poultry Production

Application of Molecular Approaches for Understanding Foodborne Salmonella Establishment in Poultry Production

Immuno-based detection of Shiga toxin-producing pathogenicEscherichia coliin food – A review on current approaches and potential strategies for optimization

Antigen Microarrays for the Study of Autoimmune Diseases

Contact Info

Product

Resources

About