Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers

Abstract

Arsenic and arsenic-derivative compounds, named as arsenicals, represent a worldwide problem for their effect on the human health and, in particular, for their capability to increase the risk of developing cancer such as kidney, bladder and prostate cancer. The main source of arsenical exposure is drinking water. Nowadays, it is well known that the chronic exposure to arsenicals leads to a series of epigenetic alterations that have a role in arsenic-induced effects on human health including cancer. Based on these observations, the aim of our study was to select by network analysis the genes/proteins/miRNAs implicated in kidney, bladder and prostate cancer development upon arsenical exposure. From this analysis we identified: (i) the nodes linking the three molecular networks specific for kidney, bladder and prostate cancer; (ii) the relative HUB nodes (RXRA, MAP3K7, NR3C1, PABPC1, NDRG1, RELA and CTNNB1) that link the three cancer networks; (iii) the miRNAs able to target these HUB nodes. In conclusion, we highlighted a panel of potential molecules related to the molecular mechanisms of arsenical-induced cancerogenesis and suggest their utility as biomarkers or therapeutic targets.

[RETRACTED ARTICLE] Suppressive effect of platycodin D on bladder cancer through microRNA-129-5p-mediated PABPC1/PI3K/AKT axis inactivation

“…This suggests that miR-129-5p may be regulated by PD, influencing the progression of bladder cancer. In addition, poly (A) binding protein cytoplasmic 1 (PABPC1), which has been identified as one of the nine HUB nodes linked to the molecular networks specific for kidney, bladder, and prostate cancers ( 10 ), was recognized as a target mRNA of miR-129-5p in the present study. Based on these findings, we hypothesize that PD treatment suppresses bladder cancer progression, potentially through the involvement of miR-129-5p.…”

“…Next, the online prediction and dual luciferase reporter assay suggested that PABPC1 was a target mRNA of miR-129-5p. PABPC1 was noted as one of the HUB nodes linked to the molecular networks specific for kidney, bladder, and prostate cancers ( 10 ). PABPC1 has also been found to be upregulated in superficial bladder cancer tissues ( 34 ).…”

Differential tissue expression of extracellular vesicle‐derived proteins in prostate cancer

“…From this list, PABPC1, CLIC1, RAB10, and PKM2 have been identified as a potential marker for (prostate) cancer. High expression of ANXA2 has been shown to have an unfavorable prognosis in multiple malignancies . Within this group of potential biomarkers, it is of interest to note that the level of expression in EVs from normal versus PCa cell lines is not always in the same direction as the NAP versus PCa tissue MS (Table ).…”

Apolipoprotein E genotype and the association between C‐reactive protein and postoperative delirium: Importance of gene‐protein interactions

“…Such gene‐protein interactions have been observed in multiple other conditions, beyond delirium and AD (e.g., cancer). This highlights that some genes operate through a moderating effect on stressors or exposures and that examining only their direct influences considers only part of the complexities of gene functional networks …”

“…This highlights that some genes operate through a moderating effect on stressors or exposures and that examining only their direct influences considers only part of the complexities of gene functional networks. [35][36][37] RESEARCH IN CONTEXT 1. Systematic review: The authors searched PubMed for studies that examined APOE and delirium, CRP and delirium, gene-protein interactions of delirium, and geneprotein interactions of Alzheimer's disease and related dementias (ADRD).…”