“… 45 Some of these differentially expressed genes have also been recently reported as markers of a proximally localized club cell subpopulation. 60 One potential explanation for such differences is that iBCs may be capable of giving rise to epithelial lineages representing molecular phenotypes of both proximal and distal airways despite their engrafted location in the trachea. Further work will be needed to test this hypothesis, including comparative profiling with intrapulmonary endogenous lineages.…”