Identification of volatile organic compounds secreted from cancer tissues and bacterial cultures

Buszewski, Bogusław; Ulanowska, Agnieszka; Ligor, Tomasz; Jackowski, Marek; Kłodzińska, Ewa; Szeliga, Jacek

doi:10.1016/j.jchromb.2008.04.038

Cited by 78 publications

(67 citation statements)

References 40 publications

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“…This phenomenon is of special interest, as it has not been previously reported. Previously, DMS was found to be substantially higher in alveolar air of patients with liver diseases and human hepatocellular carcinoma cells (HepG2) [35]. Exogenously, DMS has no significant effect on detoxification enzymes involved in carcinogen metabolism [36].…”

Section: Discussionmentioning

confidence: 99%

Rapid Identification of Cancerous Cell Lines and Evaluation of Cytotoxic Effects on Cancer Cells with VUV-PIMS

Song¹,

Wu²,

Liu³

et al. 2017

IJANER

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Section: Discussionmentioning

confidence: 99%

Rapid Identification of Cancerous Cell Lines and Evaluation of Cytotoxic Effects on Cancer Cells with VUV-PIMS

Song¹,

Wu²,

Liu³

et al. 2017

IJANER

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“…Exhaled CS 2 is also associated with gastric cancers, especially those induced by Helicobacter pylori. 184 A significant increase in CS 2 is found in human feces after eating, suggesting a role of the gut microbiome in its production. 188,189 Moreover, it is found in all samples of healthy donors and missing in many patients with foodborne bacterial infections like Campylobacter jejuni, 188 implicating a positive association of CS 2 production with a healthy gut microbiome.…”

Section: Endogenous Production?mentioning

confidence: 99%

“…1 While at present there is no direct evidence for mammalian CS 2 production by a specific mammalian enzyme, there is ancillary evidence for endogenous production. 184,185 For example, humans (controlled for exposure, medication, etc.) exhale CS 2 .…”

Section: Endogenous Production?mentioning

confidence: 99%

Carbon disulfide. Just toxic or also bioregulatory and/or therapeutic?

et al. 2017

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The overview presented here has the goal of examining whether carbon disulfide (CS 2 ) may play a role as an endogenously generated bioregulator and/or has therapeutic value. The neuro-and reproductive system toxicity of CS 2 has been documented from its long-term use in the viscose rayon industry. CS 2 is also used in the production of dithiocarbamates (DTCs), which are potent fungicides and pesticides, thus raising concern that CS 2 may be an environmental toxin. However, DTCs also have recognized medicinal use in the treatment of heavy metal poisonings as well as having potency for reducing inflammation. Three known small molecule bioregulators (SMBs) nitric oxide, carbon monoxide, and hydrogen sulfide were initially viewed as environmental toxins. Yet each is now recognized as having intricate, though not fully elucidated, biological functions at concentration regimes far lower than the toxic doses. The literature also implies that the mammalian chemical biology of CS 2 has broader implications from inflammatory states to the gut microbiome. On these bases, we suggest that the very nature of CS 2 poisoning may be related to interrupting or overwhelming relevant regulatory or signaling process(es), much like other SMBs. TOC Image 1 CONTENTS

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“…Thirty five bioactive compounds were identified in the methanolic extract of Staphylococcus aureus. GC-MS analysis of Staphylococcus aureus revealed the existence of the: Hexanoic acid , 2-methyl, 12,15-Octadecadiynoic acid , methyl ester, 1-Aminononadecane , 2,3,4,5,6,7, Cystine,3,butylamine, 3-methoxy-2-(1-methylethyl)-5-(2-methylpropyl)pyrazine, Uric acid, Thiocyanic acid 4-methoxy-2,6-dimethyl-3-pyridyl ester, 12-Dimethylamino-10-oxododecanoic acid, Glycyl-D-asparagine, Actinomycin C2, 12-Octadecenoic acid , methyl ester, 6-Octadecenoic acid , methyl ester ,(z)-, 2,5-Piperazinedione , 3,6-bis(2-methylpropyl)-, l-Leucyl-d-leucine and Methyl 12-hydroxy-9-octadecenoate. Gramineae poaceae was very highly active (6.71±0.13) mm.…”

Section: Introductionmentioning

confidence: 99%

“…Its cells form grape-like clusters, since cell division takes place in more than one plane. It is often found as a commensal associated with skin, skin glands, and mucous membranes, particularly in the nose of healthy individuals 4 . S. aureus secrets several cytolytic toxins, among them alphahemolysin, beta-hemolysin, gamma-hemolysin, leukocidin, and Panton-Valentine leukocidin (PVL) 5 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of Volatile Metabolites Released by Staphylococcus Aureus using Gas Chromatography-Mass Spectrometry and Determination of its Antifungal Activity

Jaddoa¹,

Hameed²,

Mohammed³

2016

Orient. J. Chem

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Bacterial volatile organic compounds (VOCs) have been considered as sensitive and specific biomarkers for bacterial detection in human specimens and culture media. The possibility of using VOCs markers as one of the largest groups of bacterial metabolites would open a new frontier for developing more efficient techniques in the diagnosis of bacterial infections. The aims of this research were analysis of the bioactive chemical products and evaluation of antibacterial and antifungal activity. Bioactives (chemical compounds often referred to as secondary metabolites) were analyzed using gas chromatography-mass spectroscopy (GC-MS) techniques, then the in vitro antibacterial and antifungal activity of the methanolic extract was evaluated. Thirty five bioactive compounds were identified in the methanolic extract of Staphylococcus aureus. GC-MS analysis of Staphylococcus aureus revealed the existence of the: Hexanoic acid , 2-methyl, 12,15-Octadecadiynoic acid , methyl ester, 1-Aminononadecane , 2,3,4,5,6,7, Cystine,3,butylamine, 3-methoxy-2-(1-methylethyl)-5-(2-methylpropyl)pyrazine, Uric acid, Thiocyanic acid 4-methoxy-2,6-dimethyl-3-pyridyl ester, 12-Dimethylamino-10-oxododecanoic acid, Glycyl-D-asparagine, Actinomycin C2, 12-Octadecenoic acid , methyl ester, 6-Octadecenoic acid , methyl ester ,(z)-, 2,5-Piperazinedione , 3,6-bis(2-methylpropyl)-, l-Leucyl-d-leucine and Methyl 12-hydroxy-9-octadecenoate. Gramineae poaceae was very highly active (6.71±0.13) mm. The results of anti-fungal activity produced by Staphylococcus aureus showed that the volatile compounds were highly effective to suppress the growth of Aspergillus terreus. Staphylococcus aureus produce many important secondary metabolites with high biological activities. Based on the significance of employing bioactive compounds in pharmacy to produce drugs for the treatment of many diseases, the purification of compounds produced by Staphylococcus aureus can be useful.

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Identification of volatile organic compounds secreted from cancer tissues and bacterial cultures

Cited by 78 publications

References 40 publications

Rapid Identification of Cancerous Cell Lines and Evaluation of Cytotoxic Effects on Cancer Cells with VUV-PIMS

Rapid Identification of Cancerous Cell Lines and Evaluation of Cytotoxic Effects on Cancer Cells with VUV-PIMS

Carbon disulfide. Just toxic or also bioregulatory and/or therapeutic?

Analysis of Volatile Metabolites Released by Staphylococcus Aureus using Gas Chromatography-Mass Spectrometry and Determination of its Antifungal Activity

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