Identification of viable myocardium with contrast echocardiography in patients with poor left ventricular systolic function caused by recent or remote myocardial infarction

Camarano, Gustavo; Ragosta, Michael; Gimple, Lawrence W.; Powers, Eric R.; Kaul, Sanjiv

doi:10.1016/0002-9149(95)80022-k

Cited by 61 publications

(12 citation statements)

References 24 publications

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“…As did other investigators, we observed that no reflow was statistically more common in larger infarcts (lower mean ejection fraction and higher mean wall motion score index) and that, conversely, the presence of reflow was statistically associated with both contractile reserve by dobutamine echocardiography and recovery of regional function at follow up 35 7 18 26 27 …”

Section: Discussionsupporting

confidence: 85%

Combined assessment of reflow and collateral blood flow by myocardial contrast echocardiography after acute reperfused myocardial infarction

Leclercq

Descours

et al. 1999

Heart

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Objective-To evaluate the combined assessment of reflow and collateral blood flow by myocardial contrast echocardiography after myocardial infarction. Design-Myocardial contrast echocardiography was performed in patients with acute myocardial infarction shortly after successful coronary reperfusion (TIMI 3 patency) by direct angioplasty. Collateral flow was assessed before coronary angioplasty, and contrast reflow was evaluated 15 minutes after reperfusion. The presence of contractile reserve was assessed by low dose dobutamine echocardiography (5 to 15 µg/kg/min) at (mean (SD)) 3 (2) days after myocardial infarction. Recovery of segmental function (myocardial viability) was evaluated by resting echocardiography at a two month follow up. The study was prospective. Patients-35 consecutive patients referred for acute transmural myocardial infarction. Results-Contrast reflow was observed in 20 patients (57%) and collateral flow in 14 (40%). Contrast reflow and collateral contrast flow were both correlated with reversible dysfunction on initial dobutamine echocardiography and at follow up (p < 0.05). The presence of reflow or collateral flow on myocardial contrast echocardiography was a highly sensitive (100%) but weakly specific (60%) indicator of segmental dysfunction recovery. Simultaneous presence of contrast reflow and collateral flow was more specific of reversible dysfunction than reflow alone (90% v 60%). Conclusions-Combined assessment of reflow and collateral blood flow enhanced the sensitivity of myocardial contrast echocardiography in predicting myocardial viability after acute, reperfused myocardial infarction. The simultaneous presence of reflow and collateral blood flow was highly specific of recovery of segmental dysfunction. (Heart 1999;82:62-67)

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Section: Discussionsupporting

confidence: 85%

Combined assessment of reflow and collateral blood flow by myocardial contrast echocardiography after acute reperfused myocardial infarction

Leclercq

Descours

et al. 1999

Heart

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“…Contrast echocardiography assesses perfusion through the intravenous infusion of gas-filled microbubbles, which remain intravascular and allow the quantification of myocardial blood flow velocity 31. A greater contrast enhancement has been shown to predict recovery of myocardial function 32. The main limitation of this technique despite its widespread availability and low cost is the fact that it is highly operator dependant 11.…”

Section: Assessing Viability and The Role Of Imagingmentioning

confidence: 99%

Ischaemic cardiomyopathy: pathophysiology, assessment and the role of revascularisation

Briceno

Schuster

Lumley

et al. 2016

Heart

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“…23 In this context, a method capable of defining the amount of underperfused myocardium in absolute, and percentage values would be extremely helpful in assessing changes in myocardial perfusion before and after the patency of the infarct-related artery is achieved. Because MCE is capable of establishing myocyte integrity by defining capillary perfusion, 24 its combination with RT3D has the potential to assess microcirculatory changes derived from interventions at the level of the epicardial coronary arteries.…”

Section: Discussionmentioning

confidence: 99%

Quantitative assessment of left ventricular perfusion defects using real-time three-dimensional myocardial contrast echocardiography

Camarano

Jones

Freidlin

et al. 2002

Journal of the American Society of Echocardiography

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Identification of viable myocardium with contrast echocardiography in patients with poor left ventricular systolic function caused by recent or remote myocardial infarction

Cited by 61 publications

References 24 publications

Combined assessment of reflow and collateral blood flow by myocardial contrast echocardiography after acute reperfused myocardial infarction

Combined assessment of reflow and collateral blood flow by myocardial contrast echocardiography after acute reperfused myocardial infarction

Ischaemic cardiomyopathy: pathophysiology, assessment and the role of revascularisation

Quantitative assessment of left ventricular perfusion defects using real-time three-dimensional myocardial contrast echocardiography

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