Identification of Viable Myocardium by Nitrate Echocardiography After Myocardial Infarction: Comparison with Planar Thallium Reinjection Scintigraphy

Pontillo, Daniele; Carboni, Gian Piero; Capezzuto, A; Alessi, C.; Achilli, Augusto; Piccini, Francesca; Guerra, Roberto

doi:10.1177/000331979604700502

Angiology

1996

DOI: 10.1177/000331979604700502

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Identification of Viable Myocardium by Nitrate Echocardiography After Myocardial Infarction: Comparison with Planar Thallium Reinjection Scintigraphy

Daniele Pontillo

Gian Piero Carboni²,

A Capezzuto

et al.

Abstract: NE is a reliable and low-cost method for the detection of viable noncontracting myocardium in selected patients with CAD but needs further validation for widespread application.

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Cited by 3 publications

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Technetium-99m-tetrofosmin imaging with incremental nitroglycerin infusion to detect severely ischaemic but viable myocardium: a comparative study with thallium-201???

Kula

Tutuş²,

Ünal³

et al. 2003

Nuclear Medicine Communications

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The aim of this study was to assess the influence of incremental nitroglycerin infusion (NTG+Inf) on the myocardial uptake of 99mTc-tetrofosmin (TF) in order to determine whether nitrates enhance the detection of viable myocardium with TF in patients with coronary artery disease (CAD) and left ventricular dysfunction. Fifty patients (39 males, 11 females; 54 +/- 11 years) with previous myocardial infarction and left ventricular dysfunction, who had been referred for coronary revascularization procedures, were studied. Myocardial single-photon emission tomography (SPET) images were obtained 1 h after injection of 750 MBq TF at baseline and after NTG+Inf, using a 2 day protocol. NTG+Inf was performed starting at 0.4 microg x kg(-1) x min(-1), with equal increments every 5 min up to 2 microg x kg(-1) x min(-1). Within 1 week of the TF study, rest-redistribution (R-RD) 201Tl SPET was performed after the injection of 111 MBq 201Tl. For each study, quantitative analysis was performed in 17 segments. Viability was defined as the presence of tracer uptake of > 50% of the peak activity on baseline studies or reversibility. There was significant correlation between quantitative regional RD 201Tl activity and TF activity after NTG+Inf (r = 0.90, P < 0.001). Of the 131 segments with severely reduced tracer uptake on resting TF images, 34 (26%) were reversible, showing increased tracer uptake after NTG+Inf (from 41%+/-7% to 57%+/-12% of peak activity; P < 0.001). All reversible segments after NTG+Inf had viability criteria on 201Tl studies. There was 95% concordance between TF with NTG+Inf and RD 201Tl imaging with regard to the presence of myocardial viability. We conclude that TF imaging with incremental NTG+Inf improves the detection of ischaemic but viable myocardium, correlating with the viability criteria observed on 201Tl studies. When the advantages of TF imaging are considered, rest TF imaging with NTG+Inf may be a practical diagnostic protocol in patients with CAD and left ventricular dysfunction who are being considered for revascularization.

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Technetium-99m-tetrofosmin imaging with incremental nitroglycerin infusion to detect severely ischaemic but viable myocardium: a comparative study with thallium-201???

Kula

Tutuş²,

Ünal³

et al. 2003

Nuclear Medicine Communications

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Nitroglycerin Echocardiography and Dobutamine

Pontillo

Capezzuto

1997

Angiology

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In Response

Bouki

Kranidis

1997

Angiology

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Identification of Viable Myocardium by Nitrate Echocardiography After Myocardial Infarction: Comparison with Planar Thallium Reinjection Scintigraphy

Abstract: NE is a reliable and low-cost method for the detection of viable noncontracting myocardium in selected patients with CAD but needs further validation for widespread application.

Cited by 3 publications

References 19 publications

Technetium-99m-tetrofosmin imaging with incremental nitroglycerin infusion to detect severely ischaemic but viable myocardium: a comparative study with thallium-201???

Technetium-99m-tetrofosmin imaging with incremental nitroglycerin infusion to detect severely ischaemic but viable myocardium: a comparative study with thallium-201???

Nitroglycerin Echocardiography and Dobutamine

In Response

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