Identification of various MLL gene aberrations that lead to MLL gene mutation in patients with acute lymphoblastic leukemia (ALL) and infants with acute leukemia

Cytogenetic Profile in 7209 Indian Patients with <i>de novo</i> Acute Leukemia: A Single Centre Study from India

“…The lower incidence of 2% -3% observed in the present study as well as in studies from other Asian countries indicate that MLL rearrangement incidence vary in different populations [36]. Data from previous studies from our lab supports the finding that MLL rearrangement incidence is low in Indian population [30]. The t(4;11) that is known for its adverse outcome is the common MLL translocation in childhood ALL with higher frequencies (60% -80%) in infants [61]- [63].…”

“…Fluorescence in situ hybridization (FISH) and conventional cytogenetics are the main strategies for cytogenetic workup of acute leukemia in disease management [13] [25]- [27]. Independent FISH analysis is used in several laboratories due to high sensitivity for detection of various cryptic structural and submicroscopic abnormalities, and also copy number changes in AL within short turnaround time [25]- [30].…”

5′ MLL Gene Deletion in a Case with Childhood Acute Lymphoblastic Leukemia

“…This case also had an 11q23. 2 In our case, we observed 1 fusion and 1 orange signal with the absence of a green signal in 52% of cells. G banding results revealed no involvement of chromosome 11.…”

“…2 Our patient has a deletion in the MLL gene, and Harbott and Woo's study indicated that MLL deletion was associated with good prognosis. 11,12 In the study of Takeuchi, loss of heterozygosity (LOH) of chromosome arm 11q was found in 18 of 113 primary childhood ALL samples.…”

“…[1][2][3] This gene has an important role in developmental regulation of gene expression in normal hematopoiesis. 2 The MLL gene is located on the 11q23 chromosomal region. Translocations are the most common rearrangements detected, while deletions are rarely seen.…”