Identification of ubiquitination-related hub genes in chronic myeloid leukemia cell by bioinformatics analysis
Qian Zhou,
Zhuoran Li,
Li Meng
et al.
Abstract:Purpose: Chronic myeloid leukemia stem cells (CML-LSCs) are posited as the primary instigators of resistance to tyrosine kinase inhibitors (TKIs) and recurrence of CML. Ubiquitination, a post-translational modification, has been implicated in the worsening process of CML. A more detailed understanding of their crosstalk needs further investigation. Our research aims to explore the potential ubiquitination-related genes in CML-LSC using bioinformatics analysis that might be the target for the eradication of LSC… Show more
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