Identification of two pIgR-like molecules in teleost fish with opposite roles in mucosal immunity against bacterial infection
zhen xu,
Haoyue Xu,
Zixuan Wang
et al.
Abstract:The polymeric immunoglobulin (Ig) receptor-like (pIgRL) molecules have
been identified in teleost fish. However, compare to the functional
studies of their related genes (mammalian CD300 family, et al) in
eliminating pathogen invasion while preserving homeostasis, the roles of
pIgRL in teleost fish remain unclear. In this study, we demonstrated
that a pair of pIgRL molecules in zebrafish, pIgRL3.5 and pIgRL4.2, were
highly expressed in the intestine and immune cells. Moreover, we
constructed an Edwardsiella pi… Show more
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