Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11

Circulating Long RNAs in Serum Extracellular Vesicles: Their Characterization and Potential Application as Biomarkers for Diagnosis of Colorectal Cancer

“…BCAR4 was reported to play a role in breast cancer metastasis (32). KRTAP5-4 was firstly identified in human hair roots (33). Although there are no current data regarding the relation of KRTAP5-4 to cancer, our preliminary qPCR data showed that KRTAP5-4 is expressed in cancerous tissue in the stomach, colon, and liver (raw data not shown).…”

Expression of novel keratin associated protein 5 genes in the cuticle layer of human hair follicles

“…AJ006692) genes as a KAP5 family member were identified on human chromosome 11q13 [1,3,4]. Recently, nine novel KAP5 members besides KerA and KerB have been eventually mapped on human chromosome 11p15.5 and 11q13.5 [5]. In the report, the expression of all KAP5 genes in hair roots was showed by RT-PCR, but detailed distribution pattern within hair follicles was unexplored.…”

“…To date, only two KAP5 members belonging to UHS KAP proteins have been cloned in Letter to the Editor 111 human although the presence of KAP5 genes has been predicted both on human chromosome 11p15 and 11q13 [3]. Recently, other nine KAP5 members have been identified on human chromosome 11p15.5 and 11q13.5 by homology search using the known KAP5 (KerB) gene as a query [5]. However, the expression of these KAP5 genes in situ was unclear except for KRN1/KerA [2].…”

“…AP000867) as well as the previous report (Fig. 1A) [5]. We analyzed the expression of these five KAP5 genes by RT-PCR using the cDNA of plucked hair follicles.…”

Runx1 transcription factor is involved in the regulation of KAP5 gene expression in human hair follicles

“…The KAP5 subfamily, an ultrahigh sulfur KAP (>30 mol% content), was recently characterized in human species, and consists of 11 genes located on human chromosome 11p15.5 and 11q13.5 [1]. The expression site of KAP5 genes is mostly restricted to the cuticle layer of anagen hair follicles [2].…”