Identification of two novel adenoviruses in smooth-billed ani and tropical screech owl

Oliveira, Ana Paula Jejesky de; Rangel, Maria Cristina Valdetaro; Vidovszky, Márton Z.; Rossi, João Luiz; Vicentini, Fernando; Harrach, Balázs; Kaján, Gyözö L.

doi:10.1371/journal.pone.0229415

Cited by 10 publications

(6 citation statements)

References 50 publications

(60 reference statements)

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“…Adenoviruses identified in three smooth-billed and were determined to be of genus Aviadenovirus, and had the highest pairwise amino acid sequence identity with AdV isolated from pigeons. In addition, adenoviruses identified in a tropical screech owl clustered into genus Atadenovirus, and shared 80% identity with the AdV-1 isolated from lizards [18]. The results obtained by Jejesky de Oliveira and colleagues indicate an enhanced risk of viral spread and host changes.…”

Section: Discussionmentioning

confidence: 90%

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Isolation and molecular characterization of Fowl adenovirus strains in Black grouse: First reported case in Poland

et al. 2020

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This article describes the isolation, molecular characterization, and genotyping of two fowl adenovirus (FAdVs) strains with GenBank Accession numbers (MT478054, JSN-G033-18-L and MT478055, JSN-G033-18-B) obtained from the internal organs of black grouse (Lyrurus tetrix). This study also reveals the first confirmation of fowl adenovirus in Poland, supporting one of the hypotheses about the probability of fowl adenovirus interspecies transmission. The adenovirus strain sequences were investigated via phylogenetic analysis and were found to have an overall mean pairwise distance of 2.189. The heterogeneity, Relative Synonymous Codon Usage (RSCU), codon composition, and nucleotide frequencies were examined. Statistical analyses and Tajima's test for the examined sequences were carried out. The Maximum Likelihood for the examined sequences substitutions was performed. The results of the sequence analysis identified MT478054, JSN-G033-18-L and MT478055, JSN-G033-18-B as strains of fowl adenovirus 2/11/D, with the Fowl adenovirus D complete sequence showing a 93% match. Wild birds may act as a natural reservoir for FAdVs and likely play an important role in the spreading of these viruses in the environment. The findings reported here suggest horizontal transmission within and between avian species.

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Section: Discussionmentioning

confidence: 90%

“…Adenoviral infections may be asymptomatic, or they can present with complications during the course of disease [8,[16][17][18][19][20][21][22]. Adenoviruses in birds, as compared to adenoviruses in mammals, exhibit a distinct genome organization and contain unique transcriptional units (Harrach, Chiocca, 1996).…”

Section: Introductionmentioning

confidence: 99%

Isolation and molecular characterization of Fowl adenovirus strains in Black grouse: First reported case in Poland

et al. 2020

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“…Atadenoviruses have been detected in a diverse range of hosts, including birds [ 4 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ], reptiles (order Squamata; lizards, snakes, and worm lizards), ruminants [ 8 , 9 , 15 , 19 ], marsupials [ 20 , 21 ], and a common tortoise [ 22 ]. Using a partial DNA polymerase gene sequence, recent studies also report the presence of a large number of novel atadenoviruses circulating in wild passerine species of birds in Australia and Europe and passerine species kept in aviculture collections [ 4 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterisation of a Novel and Highly Divergent Passerine Adenovirus 1

Athukorala

Forwood

Phalen

et al. 2020

Viruses

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Wild birds harbour a large number of adenoviruses that remain uncharacterised with respect to their genomic organisation, diversity, and evolution within complex ecosystems. Here, we present the first complete genome sequence of an atadenovirus from a passerine bird that is tentatively named Passerine adenovirus 1 (PaAdV-1). The PaAdV-1 genome is 39,664 bp in length, which was the longest atadenovirus to be sequenced, to the best of our knowledge, and contained 42 putative genes. Its genome organisation was characteristic of the members of genus Atadenovirus; however, the novel PaAdV-1 genome was highly divergent and showed the highest sequence similarity with psittacine adenovirus-3 (55.58%). Importantly, PaAdV-1 complete genome was deemed to contain 17 predicted novel genes that were not present in any other adenoviruses sequenced to date, with several of these predicted novel genes encoding proteins that harbour transmembrane helices. Subsequent analysis of the novel PaAdV-1 genome positioned phylogenetically to a distinct sub-clade with all others sequenced atadenoviruses and did not show any obvious close evolutionary relationship. This study concluded that the PaAdV-1 complete genome described here is not closely related to any other adenovirus isolated from avian or other natural host species and that it should be considered a separate species.

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“…rock eagle owl; Bubo bengalensis) and a Verreaux eagle owl (Bubo lacteus) with RAdV1; and tropical screech owls (Megascops choliba), involving either a novel hitherto unnamed aviadenovirus or a novel atadenovirus species. 16,20,39 Lesions associated with adenoviruses in raptors involve hepatic necrosis most consistently, with intranuclear inclusion bodies (INIBs). Other reported lesions include splenitis, nephritis, and, less commonly, lymphoid depletion of the bursa of Fabricius, ventriculitis, and proventriculitis.Our objective was to describe the gross and histologic lesions, electron microscopy (EM) findings, as well as PCR and sequencing findings of adenoviral infection in hawks from 1105240V DIXXX10.…”

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Adenoviral infection in 5 red-tailed hawks and a broad-winged hawk

et al. 2022

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Adenoviral infections among raptors are best described in falcons and are characterized most commonly by necrotizing hepatitis and splenitis; only one case has been reported in a hawk. Five red-tailed hawks ( Buteo jamaicensis) and a broad-winged hawk ( Buteo platypterus) had an adenoviral infection based on history, histopathology, negative-stain electron microscopy, and PCR. All birds had acute onset of illness resulting in death; 3 had evidence of a concurrent bacterial infection. Microscopically, all 6 birds had solitary, pale eosinophilic-to-amphophilic, intranuclear inclusion bodies within presumed hematopoietic cells in bone marrow and macrophages in spleen. Five of the 6 birds had similar inclusions within hepatocytes and Kupffer cells. All but one bird had severe bone marrow necrosis. There was moderate splenic necrosis (3 of 6) and mild-to-marked hepatic necrosis (4 of 6). Negative-stain electron microscopy demonstrated adenoviral particles in bone marrow (5 of 6), liver (1 of 5), and/or spleen (1 of 5). PCR was positive for adenovirus in bone marrow (3 of 5), liver (1 of 3), spleen (4 of 6), and/or intestinal contents (2 of 3). Viral DNA polymerase gene sequences clustered within the Siadenovirus genus. There was 99% nucleotide identity to one another and 90% nucleotide identity with the closest related adenovirus (Harris hawk, EU715130). Our case series expands on the limited knowledge of adenoviral infections in hawks. The splenic and hepatic necrosis, and particularly the hitherto unreported bone marrow necrosis, suggest that adenoviral infection is clinically relevant and potentially fatal in hawks.

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Identification of two novel adenoviruses in smooth-billed ani and tropical screech owl

Cited by 10 publications

References 50 publications

Isolation and molecular characterization of Fowl adenovirus strains in Black grouse: First reported case in Poland

Isolation and molecular characterization of Fowl adenovirus strains in Black grouse: First reported case in Poland

Molecular Characterisation of a Novel and Highly Divergent Passerine Adenovirus 1

Adenoviral infection in 5 red-tailed hawks and a broad-winged hawk

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