Identification of two new HLA‐C alleles, Cw*1203 and Cw*1402, from the sequence analysis of seven HLA homozygous cell lines carrying HLA‐C blank

Cereb, Nezih; Choi, Jin-gyu; Lee, S.; Maye, Peter; Kong, Yuan; Yang, Soo Young

doi:10.1111/j.1399-0039.1994.tb02379.x

Cited by 15 publications

(7 citation statements)

References 11 publications

(2 reference statements)

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“…6). Interestingly, another Cw12 variant, Cw*1203, is composed of the a1 domain of Cw*12021/2 and 02 domain of Cw*0602 (22). This variant was identified in a blood donor from the Mandenka population of East Senegal (Table l), while performing a largescale sequencingioligotyping analysis of this population (23).…”

Section: Sequence Of a New Cw12 Subtype In A Europeanmentioning

confidence: 99%

Sequence of four new HLA‐Cw alleles: a possible role of interallelic recombination

Grundschober¹,

Labonne

Javaux

et al. 1998

Tissue Antigens

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In order to extend our current understanding of HLA-C polymorphism, four new alleles have been cloned and sequenced: Cw*1801 in a donor of mixed origin, Cw*02024 in a Senegalese individual, Cw*1205 and Cw*1604 in European Caucasoid blood donors. HLA-Cw*1801, which most likely results from an interallelic recombination between Cw*0704 and 0401 alleles, was not associated with B*8101, but with either B*4403 or B18. The Cw*02024 allele differs from Cw*02022 by a silent mutation in exon 3. Both Cw*1801 and Cw*02024 appear to be rather frequent in populations of African origin but have not yet been detected in Caucasoids. HLA-Cw*1604 differs from Cw*1601 by two nucleotides at codon 156 leading to a Gln to Trp substitution. This new Cw16 subtype was subsequently identified in three additional unrelated families, all of South-European origin, and presented an unusual association with B*4402 in all cases. HLA-Cw*1205 is a composite allele with the alpha1 domain of Cw*1602 and the alpha2 domain of Cw*1203. It appears to be rare, at least in European Caucasoids. Three of these four alleles may have resulted from gene conversion-like or interallelic recombination events.

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Section: Sequence Of a New Cw12 Subtype In A Europeanmentioning

confidence: 99%

Sequence of four new HLA‐Cw alleles: a possible role of interallelic recombination

Grundschober¹,

Labonne

Javaux

et al. 1998

Tissue Antigens

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“…Another Cw*12 subtype was initially described by PCR-SSP as the "Cw*18-38" variant due to its association with B18 and B38 (11). It was assigned the Cw*1203 official denomination after nucleotide sequencing experiments by Cereb et al (12) and ourselves ( Figure 1). Cw*1203 is a common allele which contributes to a significant part of the HLA-C "blank" phenotype in Caucasoid and Negroid ethnic groups (2, 8,11).…”

mentioning

confidence: 99%

A new pair of HLA‐C alleles, Cw* 12042 and Cw*1203, differing at the KIR‐related dimorphism of codons 77–80

et al. 1998

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A previously unknown HLA-C variant of the Cw*12 group was identified by PCR-SSP from genomic DNA of cell NDS-JD. Molecular cloning and nucleotide sequence analysis permitted the characterization of the complete coding region of this new allele, Cw*12042. The new variant differs from the recently reported Cw*12041 by two silent changes at exons 2 and 3, and from Cw*1203 by coding changes at codons 77 and 80. Cw*1203 (Ser-Asn) and Cw*12042 (Asn-Lys) constitute the second known example of HLA-C alleles only differing at the KIR-related dimorphism of residues 77-80. The new allele is associated in cell NDS-JD with the haplotype HLA-A*2403, Cw*12042, B*51, DRB1*1502, DRB5*0102, DQB1*0601, possibly related from the evolutionary aspect to the ancestral haplotype A*2402, Cw*1202, B*5201, DRB1*1502, DRB5*0102, DQB1*0601.

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“…Sixty two 10th workshop cell lines have previously been DNA typed by a variety of methods including two from our laboratory and reported in the literature (5,6,(20)(21)(22). Our results were compared with the published ones.…”

Section: Hla-cmentioning

confidence: 99%

“…Allele designation for the cell lines (PF97387, MOU, PITOUT, OMW) that typed as Cw*1601 is more complicated. All four cell have been labeled as Cw*1601 by many laboratories including ours (5,6,21,22). PF97387 and PITOUT were defined as Cw*1601 in March 1994 (21) according to the then available EMBL sequence database in which Cw*1601 was the only Cw16 allele.…”

Section: Hla-cmentioning

confidence: 99%

Allele assignment for HLA‐A, ‐B, and ‐C genes to the Tenth International Histocompatibility Workshop cell lines

Prasad

Yang

1996

Tissue Antigens

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Development of DNA typing for Class I HLA alleles has lagged behind that of class II for a variety of technical reasons. Following the recognition of locus specific sequences in the first and the third intron, and acquiring the ability to amplify genomic DNA by intron-based PCR primer, we have devised DNA typing of class I alleles by SSOP and direct sequencing. In this study using these techniques we provide the allelic typing of HLA-A, -B, and -C genes for the B-lymphoblastoid reference cell lines from the Tenth International Histocompatibility Workshop. We also describe some common associations of the C alleles with HLA-A and HLA-B alleles.

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Identification of two new HLA‐C alleles, Cw1203 and Cw1402, from the sequence analysis of seven HLA homozygous cell lines carrying HLA‐C blank

Cited by 15 publications

References 11 publications

Sequence of four new HLA‐Cw alleles: a possible role of interallelic recombination

Sequence of four new HLA‐Cw alleles: a possible role of interallelic recombination

A new pair of HLA‐C alleles, Cw* 12042 and Cw*1203, differing at the KIR‐related dimorphism of codons 77–80

Allele assignment for HLA‐A, ‐B, and ‐C genes to the Tenth International Histocompatibility Workshop cell lines

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