Identification of tumor-specific MHC ligands through improved biochemical isolation and incorporation of machine learning
Shima Mecklenbräuker,
Piotr Skoczylas,
Paweł Biernat
et al.
Abstract:Isolation of MHC ligands and subsequent analysis by mass spectrometry is considered the gold standard for defining targets for TCR-T immunotherapies. However, as many targets of high tumor-specificity are only presented at low abundance on the cell surface of tumor cells, the efficient isolation of these peptides is crucial for their successful detection. Here, we demonstrate how different isolation strategies, which consider hydrophobicity and post-translational modifications, can improve the detection of MHC… Show more
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