1977
DOI: 10.1007/bf02624661
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Identification of tryptophan metabolites in the healthy epidermis of diabetics

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Cited by 6 publications
(3 citation statements)
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“…Previous studies assessed KP metabolites in urine [21], and skin [22] of T2D patients. Serum KYN metabolites were evaluated only in patients with diabetic retinopathy, a complication of both T2D and T1D [23].…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies assessed KP metabolites in urine [21], and skin [22] of T2D patients. Serum KYN metabolites were evaluated only in patients with diabetic retinopathy, a complication of both T2D and T1D [23].…”
Section: Discussionmentioning
confidence: 99%
“…KYN pathway of TRP metabolism could be considered as a new target for prevention and treatment of depression, and aging/aging-associated medical (e.g., IR, obesity, cardiovascular), psychiatric (e.g., vascular cognitive impairment) and other disorders associated with chronic inflammation (e.g., HCV infection [68, 69, 105], psoriasis [106, 107]) disorders.…”
Section: Brecent Developmentsmentioning
confidence: 99%
“…Secondly, it is possible that in diabetes the endogenous production of NAD from tryptophan remains at a subnormal to normal level, as indicated by findings of increased picolinic acid carboxylase activity and possibly other disturbances occurring prior to the quinolinic acid step (Figure 3)88–92. Therefore, a pyridine nucleotide deficiency, relative to the demand of an elevated glucose utilization, may occur frequently during the long‐term clinical course of diabetes32 (Figure 2).…”
Section: Chronic Disturbances Of Pyruvate Formation From Glucose and mentioning
confidence: 99%