These differences suggest that analyses aimed at estimating either relative risk of injury by comparing CIREN cases to base rates from NASS-CDS, or estimating risk of injury using control information from NASS-CDS, should be limited to a specific crash type and injury definition, and should only be performed for AIS 3+ injuries. In addition, analyses should account for the greater overall crash and injury severity of CIREN cases, at least in interpretation of the results.