Identification of transformation products of rosuvastatin in water during ZnO photocatalytic degradation through the use of associated LC–QTOF–MS to computational chemistry

Segalin, Jéferson; Sirtori, Carla; Jank, Louíse; Lima, Maria Alice Dias da Silva; Livotto, Paolo Roberto; Machado, Tiele Caprioli; Lansarin, Marla Azário; Pizzolato, Tânia Mara

doi:10.1016/j.jhazmat.2015.05.036

Cited by 17 publications

(13 citation statements)

References 24 publications

(27 reference statements)

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“…This behavior is an accordance with a previous study concerning the degradation of ROS in aqueous solutions [20] [58,59]. The value of the apparent rate constant K app is found to be 0.32 min -1 (R² = 0.992) at 30 mA, 0.53 min -1 (R² = 0.998) at 60 mA, 0.55 min -1 (R² = 0.991) at 100 mA, and 1.02 min -1 (R² = 0.996) at 300 mA.…”

Section: Effect Of Applied Currentsupporting

confidence: 93%

“…There are a few studies concerning the degradation of rosuvastatin but none approached the EF process; we have found photocatalytic degradation of rosuvastatin using ZnO catalyst in suspension [58] and in demineralised water [20]. These studies demonstrated that ROS is classified as a moderately degradable compound and the effectiveness of this process can be influenced by the presence of dissolved Zno [20]. Another study of degradation of rosuvastatin by wastewater treatment plants (WWTP) showed that the degradation rate in sludge was higher than in water because of the presence of many bacteria with a variety of enzymes Capable of catalyzing the processes of degradation of ROS.…”

mentioning

confidence: 88%

“…In our study, we chose rosuvastatin (ROS) as a model of the new generation of statins because its high consumption in many countries, especially recently, it has been approved effective against Alzheimer's disease and promising in reducing cardiovascular risk factors [19][20][21]. According to World Health Organization (WHO), ROS is the third drug most sold in the US in 2012, which explains its detection in effluent (maximum concentration of 979 ng L -1 ) and its reaction as a contaminant in natural waters [22,23].…”

mentioning

confidence: 99%

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Kinetic study of the degradation/mineralization of aqueous solutions contaminated with Rosuvastatin drug by Electro-Fenton: Influence of experimental parameters

Beqqal¹,

Yahya²,

Karbane³

et al. 2017

JMES

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Section: Effect Of Applied Currentsupporting

confidence: 93%

mentioning

confidence: 88%

mentioning

confidence: 99%

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Kinetic study of the degradation/mineralization of aqueous solutions contaminated with Rosuvastatin drug by Electro-Fenton: Influence of experimental parameters

Beqqal¹,

Yahya²,

Karbane³

et al. 2017

JMES

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“…= Obtained by HPLC retention time in agreement with method European Pharmacopoeia 7.1 g = Obtained by LC/MS in agreement with data reported in T.C. Machado et al49 h = Obtained by LC/MS in agreement with data reported in J. Segalin et al50 i = Obtained by LC/MS in agreement with data reported in S. Sulaiman et al51 …”

supporting

confidence: 82%

Treatment of statins drug (pravastatin and rosuvastatin) in water by electro-Fenton process: Kinetics of degradation/mineralization and optimization of experimental conditions for a biological post-treatment

Beqqal

Yahya²,

Miloud³

et al. 2019

Mediterr.J.Chem.,

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The treatment of pravastatin and rosuvastatin contaminated water as much as toxic and persistent organic pollutant was carried out by Electro-Fenton method EF. Several experiments were conducted in a cell compartment equipped with a platinum anode and a carbon felt cathode. The effects of several parameters such as the applied current and the catalyst Fe2+ concentration have been studied. Mineralization aqueous solutions of pravastatin followed by the chemical oxygen demand COD gave a higher degree of reduction of more than 90% for 6 hours of treatment at a current of 100 mA and Fe2+ concentration of 0.2 mM. The study of the degradation kinetics was followed during electrolysis by HPLC giving a pseudo first order reaction using a current of 100 mA and Fe2+ concentration of 0.1mM. A number of intermediate products for pravastatin and rosuvastatin have been identified using HPLC and liquid chromatography-mass spectrometry analyses. Biodegradability of the pre-treated solutions of two statins by EF was evaluated in order to decide the optimal moment to introduce the biological process. It was given by the ratio BOD5/COD which increases from 0 initially to 1.3 after 2 hours for pravastatin and from 0 initially to 1.5 after 3 hours for rosuvastatin as the COD decreases. It implies that EF tends to enhance the biodegradability and could be used as a pre-treatment step for biological treatment.

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“…Therefore, when the initial pH is 5, the stronger electrostatic forces can enhance the attachment of anionic species derived from the primary target molecule or its intermediates. This phenomenon favors the adsorption of these species and their latter oxidation [11,31,32].…”

Section: Signal-to-noise Ratios Of Initial Ph and Catalyst Loadmentioning

confidence: 98%

Photocatalytic Degradation of Commercial Acetaminophen: Evaluation, Modeling, and Scaling-Up of Photoreactors

et al. 2018

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Abstract:In this work, the performance of a pilot-scale solar CPC reactor was evaluated for the degradation of commercial acetaminophen, using TiO 2 P25 as a catalyst. The statistical Taguchi's method was used to estimate the combination of initial pH and catalyst load while tackling the variability of the solar radiation intensity under tropical weather conditions through the estimation of the signal-to-noise ratios (S/N) of the controllable variables. Moreover, a kinetic law that included the explicit dependence on the local volumetric rate of photon absorption (LVRPA) was used. The radiant field was estimated by joining the Six Flux Model (SFM) with a solar emission model based on clarity index (K C ), whereas the mass balance was coupled to the hydrodynamic equations, corresponding to the turbulent regime. For scaling-up purposes, the ratio of the total area-to-total-pollutant volume (A T /V T ) was varied for observing the effect of this parameter on the overall plant performance. The Taguchi's experimental design results showed that the best combination of initial pH and catalyst load was 9 and 0.6 g L −1 , respectively. Also, full-scale plants would require far fewer ratios of A T /V T than for pilot or intermediate-scale ones. This information may be beneficial for reducing assembling costs of photocatalytic reactors scaling-up.

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Identification of transformation products of rosuvastatin in water during ZnO photocatalytic degradation through the use of associated LC–QTOF–MS to computational chemistry

Cited by 17 publications

References 24 publications

Kinetic study of the degradation/mineralization of aqueous solutions contaminated with Rosuvastatin drug by Electro-Fenton: Influence of experimental parameters

Kinetic study of the degradation/mineralization of aqueous solutions contaminated with Rosuvastatin drug by Electro-Fenton: Influence of experimental parameters

Treatment of statins drug (pravastatin and rosuvastatin) in water by electro-Fenton process: Kinetics of degradation/mineralization and optimization of experimental conditions for a biological post-treatment

Photocatalytic Degradation of Commercial Acetaminophen: Evaluation, Modeling, and Scaling-Up of Photoreactors

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