Identification of the Transcriptional Regulatory Role of RUNX2 by Network Analysis in Lung Cancer Cells

Otálora‐Otálora, Beatriz Andrea; Prieto, Cristian González; Guerrero, Lucia; Bernal-Forigua, Camila; Montecino, Martín; Cañas, Alejandra; López‐Kleine, Liliana; Rojas, Alejandra

doi:10.3390/biomedicines10123122

Cited by 4 publications

(2 citation statements)

References 83 publications

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“…In our lung cancer bioinformatic analysis of TF RUNX2 [48], we analyzed and compared our pipeline and results [38,49] with previous studies, finding eleven publications assessing the lung cancer TRN with different microarray and RNA-seq studies; we also performed direct and very different bioinformatics analyses on datasets created or selected from the databases. Four studies were led with cell lines; five were made with one, two, or six microarray studies; and two were conducted with TCGA RNA-seq studies.…”

Section: Lung Cancermentioning

confidence: 99%

Host Transcriptional Regulatory Genes and Microbiome Networks Crosstalk through Immune Receptors Establishing Normal and Tumor Multiomics Metafirm of the Oral-Gut-Lung Axis

Otálora-Otálora,

López-Rivera,

Aristizábal-Guzmán

et al. 2023

IJMS

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The microbiome has shown a correlation with the diet and lifestyle of each population in health and disease, the ability to communicate at the cellular level with the host through innate and adaptative immune receptors, and therefore an important role in modulating inflammatory process related to the establishment and progression of cancer. The oral cavity is one of the most important interaction windows between the human body and the environment, allowing the entry of an important number of microorganisms and their passage across the gastrointestinal tract and lungs. In this review, the contribution of the microbiome network to the establishment of systemic diseases like cancer is analyzed through their synergistic interactions and bidirectional crosstalk in the oral-gut-lung axis as well as its communication with the host cells. Moreover, the impact of the characteristic microbiota of each population in the formation of the multiomics molecular metafirm of the oral-gut-lung axis is also analyzed through state-of-the-art sequencing techniques, which allow a global study of the molecular processes involved of the flow of the microbiota environmental signals through cancer-related cells and its relationship with the establishment of the transcription factor network responsible for the control of regulatory processes involved with tumorigenesis.

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Section: Lung Cancermentioning

confidence: 99%

Host Transcriptional Regulatory Genes and Microbiome Networks Crosstalk through Immune Receptors Establishing Normal and Tumor Multiomics Metafirm of the Oral-Gut-Lung Axis

Otálora-Otálora,

López-Rivera,

Aristizábal-Guzmán

et al. 2023

IJMS

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“…The deletion of the RUNT domain using the CRISPR/Cas9 technique lowered the cancer cell migration by a considerable margin [36], while its presence contributed to increased osteotropism and bone invasion in melanoma cells [37]. RUNX2 has also been shown to promote the aggressiveness of malignant gliomas [38] and act as a master transcriptional regulator in lung cancer [39] and in possibly all other cancers. RUNX2 is also a key epigenetic enhancer of tumor metastasis, stemness and resistance to therapy [40].…”

Section: Approachmentioning

confidence: 99%

Paving Way for a Paradigm Shift in Oncology: Curing Cancer by Loving It?

Uskoković

2023

Micro

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Plateaus in the efficacy of traditional methods for the treatment of cancer reached in the last decades call for the exploration of alternative models as their potential clinical complements. Here, the classical view of cancer as a tissue that is to be eradicated by methods describable by a compendium of militaristic metaphors is being challenged with a provocative idea: what if cancer can be cured with love condensed down to the level of molecular and cell biology? Correspondingly, the idea that love mimics the traits of the objects of its affection and helps them grow was translated to the level of cell biology by incorporating anti-apoptotic properties in healthy cells and promoting tumorigenesis in cancerous cells. Both the indirect and direct co-culture of the two cell types demonstrated hindered growth of cancer cells relative to that of their primary counterparts when these cellular modifications inspired by love for cancer were being implemented. The two experimental models reported here are emphasized as crude and simplistic methods derived from the idea that cancer may be best treated by being loved at the cellular and molecular biology levels. More comprehensive and effective methods may emanate from continued exploration and expansion of the intriguing and innovative avenue for cancer management proposed here.

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RUNX2 as a Prognostic Factor in Human Cancers

Toner,

Gordon,

Greenyer

et al. 2024

Crit Rev Eukaryot Gene Expr

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The RUNX2 transcription factor was discovered as an essential transcriptional regulator for commitment to osteoblast lineage cells and bone formation. Expression of RUNX2 in other tissues, such as breast, prostate, and lung, has been linked to oncogenesis, cancer progression, and metastasis. In this study, we sought to determine the extent of RUNX2 involvement in other tumors using a pan-cancer analysis strategy. We correlated RUNX2 expression and clinical-pathological parameters in human cancers by interrogating publicly available multiparameter clinical data. Our analysis demonstrated that altered RUNX2 expression or function is associated with several cancer types from different tissues. We identified three tumor types associated with increased RUNX2 expression and four other tumor types associated with decreased RUNX2 expression. Our pan-cancer analysis for RUNX2 revealed numerous other discoveries for RUNX2 regulation of different cancers identified in each of the pan-cancer databases. Both up and down regulation of RUNX2 was observed during progression of specific types of cancers in promoting the distinct types of cancers.

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Identification of the Transcriptional Regulatory Role of RUNX2 by Network Analysis in Lung Cancer Cells

Cited by 4 publications

References 83 publications

Host Transcriptional Regulatory Genes and Microbiome Networks Crosstalk through Immune Receptors Establishing Normal and Tumor Multiomics Metafirm of the Oral-Gut-Lung Axis

Host Transcriptional Regulatory Genes and Microbiome Networks Crosstalk through Immune Receptors Establishing Normal and Tumor Multiomics Metafirm of the Oral-Gut-Lung Axis

Paving Way for a Paradigm Shift in Oncology: Curing Cancer by Loving It?

RUNX2 as a Prognostic Factor in Human Cancers

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