Identification of the toxic trigger in mushroom poisoning

Matsuura, Masanori; Saikawa, Yoshirou; Inui, Kosei; Nakae, Koichi; Igarashi, Masayuki; Hashimoto, Kimiko; Nakata, Masaya

doi:10.1038/nchembio.179

Cited by 82 publications

(66 citation statements)

References 16 publications

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“…Patients may recover or may present with delayed complaints of muscle pain and weakness, with associated rhabdomyolysis, myoglobinuria, renal failure, and hyperkalemia. Speech impairment, convulsions, and loss of consciousness have also been reported [143,144].…”

Section: Clinical Presentationmentioning

confidence: 95%

“…subnigricans contains cycloprop-2-ene carboxylic acid, which triggers rhabdomyolysis [143]. In Asia, ingestion of R. subnigricans typically results in nausea, vomiting, and diarrhea within 30 min to 2 h of ingestion.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…When patients recover, they may experience muscle weakness for several weeks to months [71,72,143,144].…”

Section: Clinical Presentationmentioning

confidence: 99%

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Mycetism: A Review of the Recent Literature

Graeme

2014

J. Med. Toxicol.

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Approximately 100 of the known species of mushrooms are poisonous to humans. New toxic mushroom species continue to be identified. Some species initially classified as edible are later reclassified as toxic. This results in a continually expanding list of toxic mushrooms. As new toxic species are identified, some classic teachings about mycetism no longer hold true. As more toxic mushrooms are identified and more toxic syndromes are reported, older classification systems fail to effectively accommodate mycetism. This review provides an update of myscetism and classifies mushroom poisonings by the primary organ system affected, permitting expansion, as new, toxic mushroom species are discovered.

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Section: Clinical Presentationmentioning

confidence: 95%

Section: Clinical Presentationmentioning

confidence: 99%

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Mycetism: A Review of the Recent Literature

Graeme

2014

J. Med. Toxicol.

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“…Apsinuodijimas nuodingąja ūmėde ir žalsvuoju baltiku (Tricholoma equestre) gali sukelti rabdomiolizę, ūminį inkstų nepakankamumą, sunkų elektrolitų disbalansą (hiperkalemiją, hipokalcemiją), kvėpavimo sistemos nepkankamumą, plaučių edemą, skilvelinę tachikardiją ir kardiovaskulinį šoką [1,5,6,29,32]. Kai kuriais atvejais rabdomiolizė pažeidžia ne tik inkstus ir sutrigdo elektrolitų balansą, bet ir sukelia miokarditą, aritmijas, kardiovaskulinį kolapsą ir baigiasi mirtimi [29].…”

Section: Rabdomiolizės Sindromasunclassified

Dažniausi Apsinuodijimo Grybais Sindromai Ir Inkstų Pažeidimai

Rėkutė¹,

Miglinas

Rimševičius

2017

Medicinos Teorija Ir Praktika

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SANTRAUKAReikšminiai žodžiai: grybai, apsinuodijimai, amanitinas, orelaninas, inkstai. Apsinuodijimas grybais yra reta ūminių inkstų ir kepenų pažeidimų priežastis, tačiau gali sukelti rimtų sveikatos sutrikimų ir baigtis mirtimi. Lietuvoje dažniausiai apsinuodijama musmirėmis (Amanita genties grybais) ir nuodingaisiais nuosėdžiais (Cortinarius orellanus), kurie atitinkamai sukelia Amanitino ir Orelano sindromus. Užsienyje nustatyta rabdomiolizės sukeltų mirties atvejų apsinuodijus nuodingąja ūmėde (Russula subnigricans). Apsinuodijus grybais, atsiranda ankstyvųjų simptomų -pykinimas, vėmimas, viduriavimas, arba vėlyvųjų -negrįžtamų inkstų ir kepenų pažeidimų, elektrolitų disbalansas, kvėpa-vimo ir kardiovaskulinės sistemos pokyčių. Intoksikacijos veikimo mechanizmas siejamas su DNR bei RNR sintezės inhibicija, oksidaciniais ląstelės pažeidimais. Lietuvoje diagnozė remiasi klinika ir surinkta anamneze, užsienyje atliekama inkstų biopsija ir ieškoma histologinių pokyčių. Specifinio gydymo nėra. Efektyviausias gydymas -palaikomasis: agresyvus skysčių atstatymas, elektrolitų balanso palaikymas, gyvybiškai svarbių funkcijų stabilizavimas. Sunkiais atvejais atliekama inkstų ar/ ir kepenų transplantacija. Norint apsaugoti save ir aplinkinius nuo apsinuodijimo grybais, svarbu atpažinti valgomus grybus, tinkamai apdoroti prieš valgant bei riboti vartojamų grybų kiekį. ABSTRACTKey words: mushrooms, poisoning, amanitin, orellanine, kidney. Although mushroom poisoning is a rare cause of renal and liver diseases, it can result in serious health problems and even death. In Lithuania, the most common poisonous mushrooms are Amanita phalloides (Amanita family) and Cortinarius orellanus (Cortinarius family), which respectively causes Amanitin and Orellanus syndromes. In foreign countries, Russula subnigricans (Russulaceae family) poisoning it is not unusual, which may cause rhabdomyolysis induced death. Early symptoms of mushroom poisoning are sickness, vomiting, diarrhea, while advanced symptoms include irreversible kidney and liver injury, electrolytes imbalance, respiratory and cardiovascular system disorders. Mushroom caused intoxication is linked with DNA and RNA synthesis inhibition and oxidative cell damage. In Lithuania, mushroom poisoning diagnosis is primarily based on clinical evidence and anamnesis, while in foreign countries kidney biopsy is also a common procedure. However, there is no specific therapy for mushroom poisoning and, hence, treatment is mainly supportive. In severe cases, kidney or/and liver transplantation may be necessary. Serious health disorders, which result from mushroom poisoning, highlight the importance to spread knowledge about the potential nephrotoxicity of mushrooms, proper preparation and even limited consumption. Skirmantė Rėkutė VUL Santariškių klinikos Santariškių g. 2, Vilnius

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“…Furthermore, 5 was stable in aqueous solutions containing L-cysteine, both at room temperature and after heating at 60°C (Figure S3), in agreement with previous studies on related methylcyclopropenes. [19] Interestingly, when heated to 60°C in the presence of Lcysteine, we found that trans-cyclooctenol [rel-(1R,4E,pR)-cyclooct-4-enol] isomerized slowly to cis-cyclooctenol ( Figure S4). Although further work will be needed to determine the relevance of this phenomenon for bioconjugation, it does illustrate that, under certain conditions, methylcyclopropenes may possess superior stability to trans-cyclooctenes, because cyclopropenes are not subject to this cis/trans isomerization.…”

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confidence: 99%

Live‐Cell Imaging of Cyclopropene Tags with Fluorogenic Tetrazine Cycloadditions

et al. 2012

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There is growing interest in the use of inverse Diels-Alder tetrazine cycloadditions as rapid catalyst-free bioorthogonal reactions. [1][2][3] Fluorogenic tetrazines that increase in fluorescence after reaction with dienophiles are particularly useful for live-cell imaging applications. [4] Fluorogenic tetrazines have been recently used for live-cell imaging of small molecules, biomolecules tagged enzymatically with dienophiles, and proteins modified by reactive unnatural amino acids. [4,5] Although fluorogenic tetrazine probes hold great potential for intracellular imaging of small molecules, previous approaches are limited by requiring a large strained dienophile, such as trans-cyclooctene, cyclooctyne, or norbornene. [1,6] This situation is in contrast to Staudinger ligations or strain-promoted azide-cycloalkyne cycloadditions that utilize a small azide functional group. [7,8] This requirement has limited the use of tetrazine reactions in methods that require tags with minimal steric impact or nominal effect on the partition ratio. [2] The development of smaller dienophile partners capable of reacting rapidly with tetrazines would therefore represent a major advance. However, it has been unclear whether small dienophiles could be developed that react rapidly with tetrazines while maintaining their stability. Herein, we demonstrate the applicability of methylcyclopropene tags as dienophiles for reaction with fluorogenic tetrazines. Through systematic synthetic modifications we have optimized the stability, size, and reactivity of the cyclopropene scaffold. We have developed methylcyclopropene derivatives that react rapidly with tetrazines while retaining their aqueous stability and small size. These cyclopropene handles elicit fluorescent responses from quenched tetrazine dyes and are suitable for cellular imaging applications, which we demonstrate by imaging cyclopropene phospholipids distributed in live human breast cancer cells.The use of cyclopropenes offers a possible approach to smaller dienophile partners for tetrazine cycloadditions. It has long been known that cyclopropenes react rapidly with tetrazines to form stable diazanorcaradienes (Figure 1a). [9] In seminal work, Sauer and coworkers demonstrated that unsubstituted cyclopropene reacts with dimethyl 1,2,4,5-** We greatly acknowledge Ralph Mazitschek, Michael Hardy, and Carlos Guerrero for helpful discussions.

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Identification of the toxic trigger in mushroom poisoning

Cited by 82 publications

References 16 publications

Mycetism: A Review of the Recent Literature

Mycetism: A Review of the Recent Literature

Dažniausi Apsinuodijimo Grybais Sindromai Ir Inkstų Pažeidimai

Live‐Cell Imaging of Cyclopropene Tags with Fluorogenic Tetrazine Cycloadditions

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