“…3). The archetypal G s -adenylyl cyclase-PKA cascade enhances GIRK's P o through phosphorylation of the channel subunits on defined C-terminal amino acids residues (Medina et al, 2000;Mullner, Steinecker, Gorischek, & Schreibmayer, 2009;Mullner et al, 2000;Mullner, Yakubovich, Dessauer, Platzer, & Schreibmayer, 2003;Rusinova et al, 2009). Phosphorylation by PKA has been proposed to serve as an "on-switch" for channel activation by Gβγ itself, with dephosphorylation by protein phosphatase 2A turning off the channel (Medina et al, 2000).…”