Identification of the role of MCM6 in bladder cancer prognosis, immunotherapy response, and in vitro experimental investigation using multi-omics analysis

Wang, Jirong; Li, Xiaoran; Chen, Siyu; Cao, Jinlong; Fan, Xinpeng; Wang, Huabin; Zhang, Xingxing; Yang, Li

doi:10.1016/j.lfs.2023.122253

Cited by 1 publication

(1 citation statement)

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“…A similar basis can be used for CDC25 as was used for MCM6 (mini-chromosome maintenance), a vital protein for chromosome stability. Proteomics has linked other members within this protein family, finding overexpression between cancerous and normal tissue, particularly in bowel cancer (Wang et al, 2023). The utility of proteomics was not just singled out to this check-point inhibitor, Proteolysis targeting chimera D6 in triple-negative breast cancer along a CDC25-CDK1 axis was found by comparing triple-negative breast cancer cell line response against D6 (Wu Y. et al, 2024).…”

Section: Introduction To Molecular Profiling Techniques For Identifyi...mentioning

confidence: 99%

Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine

Dakilah,

Harb,

Abu-Gharbieh

et al. 2024

Front. Pharmacol.

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The global burden of cancer continues to rise, underscoring the urgency of developing more effective and precisely targeted therapies. This comprehensive review explores the confluence of precision medicine and CDC25 phosphatases in the context of cancer research. Precision medicine, alternatively referred to as customized medicine, aims to customize medical interventions by taking into account the genetic, genomic, and epigenetic characteristics of individual patients. The identification of particular genetic and molecular drivers driving cancer helps both diagnostic accuracy and treatment selection. Precision medicine utilizes sophisticated technology such as genome sequencing and bioinformatics to elucidate genetic differences that underlie the proliferation of cancer cells, hence facilitating the development of customized therapeutic interventions. CDC25 phosphatases, which play a crucial role in governing the progression of the cell cycle, have garnered significant attention as potential targets for cancer treatment. The dysregulation of CDC25 is a characteristic feature observed in various types of malignancies, hence classifying them as proto-oncogenes. The proteins in question, which operate as phosphatases, play a role in the activation of Cyclin-dependent kinases (CDKs), so promoting the advancement of the cell cycle. CDC25 inhibitors demonstrate potential as therapeutic drugs for cancer treatment by specifically blocking the activity of CDKs and modulating the cell cycle in malignant cells. In brief, precision medicine presents a potentially fruitful option for augmenting cancer research, diagnosis, and treatment, with an emphasis on individualized care predicated upon patients’ genetic and molecular profiles. The review highlights the significance of CDC25 phosphatases in the advancement of cancer and identifies them as promising candidates for therapeutic intervention. This statement underscores the significance of doing thorough molecular profiling in order to uncover the complex molecular characteristics of cancer cells.

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Section: Introduction To Molecular Profiling Techniques For Identifyi...mentioning

confidence: 99%

Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine

Dakilah,

Harb,

Abu-Gharbieh

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

Identification of the role of MCM6 in bladder cancer prognosis, immunotherapy response, and in vitro experimental investigation using multi-omics analysis

Cited by 1 publication

References 44 publications

Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine

Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine

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