Identification of the Risk Factors Associated with Helicobacter pylori Infection in Lahore, Pakistan

Ali, Ashfaq; Ahmad, Muhammad Riaz; Iqbal, Zafar; Basit, Abdul

doi:10.4172/2155-6180.1000348

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…The risk factors for H. pylori infection are sex (10) , age (11,12) , smoking (13) , alcohol consumption (14) , contaminated food (12) , untreated water intake (5) , family size (15) , bed sharing (16) , poor living conditions in childhood (17) , educational (13) and socioeconomic level (18) , hygiene (19) , and family medical history of gastric disease (11) .…”

Section: Introductionmentioning

confidence: 99%

[Article Partial Retraction] Prevalence of Helicobacter Pylori Infection in Dyspeptic Patients and Its Association With Clinical Risk Factors for Developing Gastric Adenocarcinoma

Borges

Ramos

Filho

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: In Brazil, particularly in the underdeveloped localities, the prevalence of Helicobacter pylori (H. pylori) infections can range up to 90%. These rates are higher in older individuals and vary by country region. H. pylori infections are linked to the development of gastric pathologies, namely mild to moderate gastritis, gastroenteritis, peptic ulcer, intestinal metaplasia, and gastric cancer. In 1994, this organism was classified by the International Agency for Research on Cancer (IARC) as pertaining to the Group 1 carcinogen for gastric adenocarcinoma etiology. Gastric cancer represents a significant public health problem, being the fourth most common malignant tumor and the second largest cause of cancer-related deaths. OBJECTIVE: To investigate the prevalence of H. pylori infection in dyspeptic patients and determine the link between clinical risk factors and gastric adenocarcinoma diagnosis. METHODS: Polymerase chain reaction (PCR) analysis was employed for molecular diagnosis of gastric tissue biopsies collected from 113 dyspeptic patients at the University Hospital of Federal University of Goiás. Molecular analyses allowed the identification of H. pylori infections. Furthermore, histopathological examinations were performed to determine the clinical risks of developing gastric malignancies. RESULTS: The test results identified 69 individuals older than 44 years, from 75 (66.4%) positive H. pylori infection samples. The prevalence of gastric adenocarcinoma in this study was 1.3%. Among the infected patients, six (8.2%) had high risk, and 67 (91.8%) had a low risk of developing gastric cancer (P<0.05). CONCLUSION: This study shows a high prevalence of H. pylori infection and identifies its contribution to gastric inflammations, which in the long term are manifested in high-risk clinical factors for the development of gastric adenocarcinoma.

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Section: Introductionmentioning

confidence: 99%

[Article Partial Retraction] Prevalence of Helicobacter Pylori Infection in Dyspeptic Patients and Its Association With Clinical Risk Factors for Developing Gastric Adenocarcinoma

Borges

Ramos

Filho

et al. 2019

Arq. Gastroenterol.

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show abstract

“…Alebie et al (2016) in a study that included 145 Ethiopian students with gastritis found that consumption of coffee exacerbates H. pylori related gastritis symptoms [ 28 ]. Monno et al (2019) in a retrospective study conducted in Italy revealed that the frequent consumption of coffee increases the H. pylori infection rate [ 18 ], while other studies did not find any association between coffee consumption and H. pylori infection [ 10 , 29 , 30 ]. The relationship between coffee consumption and H. pylori infection might be attributed to the differences in the type of coffee consumed and preparation methods.…”

Section: Discussionmentioning

confidence: 99%

“…However, it was reported that frequent consumption of coffee was associated with an increased rate of H. pylori infection and exacerbation of H. pylori -related gastritis symptoms [ 18 , 28 ]. Some studies did not find any association between coffee consumption and H. pylori infection [ 10 , 29 , 30 ]. In addition, the relationship between H. pylori infection and several modifiable cardio-metabolic risk factors was reported in the literature [ 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Dietary Habits and Helicobacter pylori Infection among Bahraini Adults

et al. 2022

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Helicobacter pylori (H. Pylori) infection is the main bacterial cause of several gastrointestinal disorders. This study aims to estimate the prevalence of H. pylori infection in a population of Bahraini adults seeking care in gastroenterology clinics in a tertiary care hospital in the Kingdom of Bahrain and examine the association between dietary habits and other factors with H. pylori infection. The study is a hospital-based retrospective, cross-sectional analytical study that included 200 participants. H. pylori infection prevalence among the studied group was 55.5%, and it was significantly higher among participants with a high school education or less (44.1%). Among dietary habits, the mean of frequency of green tea, coffee and honey intake was significantly lower among the H. pylori infected participants compared to their non-infected counterparts. H. pylori infection was significantly higher among participants with vitamin D deficiency (63.6%) compared to participants with normal vitamin D (30%) (p = 0.001) and each unit decrease in serum vitamin D was associated with an increased risk of infection by 1.1 times (OR = 1.1; 95% CI: 1.05, 1.18; p < 0.001). The study revealed that high educational levels, consumption of honey, green tea, and coffee, as well as normal serum vitamin D level, were independent protectors against H. pylori infection. Additional studies are needed to estimate the prevalence and predisposing factors of H. pylori infection in the general population.

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Seroprevalence of Anti-Helicobacter pylori and Anti-CagA IgG Antibodies in Iranian Dyspeptic Patients

Afzali¹,

Mandegary²,

Alimolaei³

et al. 2018

Int J Enteric Pathog

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Background: Helicobacter pylori, a worldwide infection, is associated with several infectious diseases including gastric ulcer, peptic ulcer, and gastric cancer resulting from the cytotoxinassociated gene A (CagA). The purpose of this study was to evaluate the seroprevalence of anti-H. pylori and anti-CagA IgG antibodies in Iranian dyspeptic patients. Methods: In this prospective epidemiological survey, a total of 659 patients were evaluated for the presence of general anti-H. pylori IgG, and then for anti-CagA IgG by two commercial ELISA kits. Results: The prevalence of general anti-H. pylori IgG was 58.1% (383 of 659 patients) which increased progressively with age (P < 0.05) and was not significantly influenced by the sex (P = 0.08). The prevalence of anti-CagA IgG antibody in seropositive and seronegative patients for general H. pylori IgG was 52.9% (37 of 70) and 61.9% (13 of 21), respectively. Conclusion: This is the first report on the high prevalence of anti-CagA IgG in both seropositive and seronegative patients for general IgG, indicating the importance of this antibody in diagnosis of H. pylori positive patients after seroconversion of the general IgG.

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Identification of the Risk Factors Associated with Helicobacter pylori Infection in Lahore, Pakistan

Abstract: Citation: Ali A, Ahmad MR, Iqbal Z, Basit A (2017) Identification of the Risk Factors Associated with Helicobacter pylori Infection in Lahore, Pakistan.

Cited by 3 publications

References 17 publications

[Article Partial Retraction] Prevalence of Helicobacter Pylori Infection in Dyspeptic Patients and Its Association With Clinical Risk Factors for Developing Gastric Adenocarcinoma

[Article Partial Retraction] Prevalence of Helicobacter Pylori Infection in Dyspeptic Patients and Its Association With Clinical Risk Factors for Developing Gastric Adenocarcinoma

Association between Dietary Habits and Helicobacter pylori Infection among Bahraini Adults

Seroprevalence of Anti-Helicobacter pylori and Anti-CagA IgG Antibodies in Iranian Dyspeptic Patients

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