“…HPV16 E6 was shown to interact in vitro with the karyopherins ␣2, 1, and 2 (37), suggesting that E6 is actively imported in the nucleus. Our subcellular localization of the 29 HPV E6 proteins used in this study, as fusions with YFP, showed that the E6 proteins from HPV types 11,16,18,26,30,31,33,34,35,39,42,45,51,52,53,56,58,59,66,68,69,70,73,82,83, and 97 accumulate predominantly in the nucleus after transfection (Fig. 5).…”