Identification of the Proteins Determining the Blood Circulation Time of Nanoparticles

Marques, Cintia; Hajipour, Mohammad Javad; Marets, Célia; Oudot, Alexandra; Safavi‐Sohi, Reihaneh; Guillemin, M.; Borchard, Gerrit; Jordan, Olivier; Saviot, Lucien; Maurizi, Lionel

doi:10.1021/acsnano.3c02041

Cited by 21 publications

(8 citation statements)

References 76 publications

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“…In contrast, if more dysopsonins are adsorbed, then nanoparticles can have more time and a higher opportunity to reach the target tissues. Moreover, Maurizi et al identified the hard corona proteins that determine the retention time of superparamagnetic iron oxide nanoparticles in the blood circulation system. It was found that the protein corona composition, such as hemoglobin, can regulate the circulation time and clearance of these ultrasmall nanoparticles, and the increased content of hemoglobin on the surfaces of positively charged nanoparticles dictated most of the circulation time.…”

Section: Features Of the In Vivo Protein Corona Formation Of Nanopart...mentioning

confidence: 99%

Perspectives on Protein–Nanoparticle Interactions at the In Vivo Level

He,

Qu,

Shang

2024

Langmuir

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The distinct features of nanoparticles have provided a vast opportunity of developing new diagnosis and therapy strategies for miscellaneous diseases. Although a few nanomedicines are available in the market or in the translation stage, many important issues are still unsolved. When entering the body, nanomaterials will be quickly coated by proteins from their surroundings, forming a corona on their surface, the so-called protein corona. Studies have shown that the protein corona has many important biological implications, particularly at the in vivo level. For example, they can promote the immune system to rapidly clear these outer materials and prevent nanoparticles from playing their designed role in therapy. In this Perspective, the available techniques for characterizing protein−nanoparticle interactions are critically summarized. Effects of nanoparticle properties and environmental factors on protein corona formation, which can further regulate the in vivo fate of nanoparticles, are highlighted and discussed. Moreover, recent progress on the biomedical application of protein corona-engineered nanoparticles is introduced, and future directions for this important yet challenging research area are also briefly discussed.

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Section: Features Of the In Vivo Protein Corona Formation Of Nanopart...mentioning

confidence: 99%

Perspectives on Protein–Nanoparticle Interactions at the In Vivo Level

He,

Qu,

Shang

2024

Langmuir

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“…5 However, it works as an iron supplement instead of a T 2 MRI contrast agent nowadays owing to its relatively low T 2 contrast and undesirable behavior in vivo. 2,6,7 Therefore, developing effective strategies to enhance the contrast efficiency of IONP-based materials has become an urgent demand as they can be translated into clinical applications.…”

Section: ■ Introductionmentioning

confidence: 99%

Cubic Zinc-Doped Iron Oxide Nanoparticles with Poly(Ethylene Glycol) or Sodium Citrate Surface Coatings for Tumor Imaging

Sun,

Tan,

Fang

et al. 2024

ACS Appl. Nano Mater.

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Magnetic resonance imaging (MRI) has been extensively studied over the past few decades, so developing strategies to enhance the T 2 contrast is of significant importance. Herein, we synthesized a series of cubic zinc-doped iron oxide nanoparticles (CZINs) with different dopant ratios by the thermal decomposition method. CZINs with a dopant ratio of 1:5 show the best magnetic performance and T 2 relaxivity among all CZINs. More importantly, we demonstrate that differentiated surface modifications lead to diverse in vivo behavior of CZINs, resulting in the distinct contrast efficiency for different types of tumor. Compared to sodium citrate (SC)-modified CZINs, polyethylene glycol (PEG)-modified CZINs show lower protein absorption, longer blood circulation time, and lower uptake amount in liver. These behavior differences lead PEG-modified CZINs to be potential candidates for assisting precise subcutaneous tumor diagnosis, while SC-modified CZINs are more suitable for achieving accurate liver metastases imaging. This research holds significant promise to develop potential T 2 contrast agents, which can be translated into clinical practice.

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“…We showed that both protein content and composition change over time in the animal body ( in vivo experiments). 16 The protein exchange on the NPs affects their retention time in the blood circulation system. Any changes in the content of proteins extending (dysopsonins) and/or shortening (opsonins) the NP circulation time can affect the plasma half-life of NPs.…”

Section: Introductionmentioning

confidence: 99%

“…Any changes in the content of proteins extending (dysopsonins) and/or shortening (opsonins) the NP circulation time can affect the plasma half-life of NPs. 16 Opsonins are a group of proteins that enhance the phagocytosis of foreign particles by immune cells, such as macrophages and neutrophils. Opsonization of nanoparticles can lead to their rapid clearance from circulation and accumulation in the liver and spleen, which can limit their therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…We identified new proteins acting as opsonins and/or dysopsonis, and change over time. 16 The protein replacement on the NP surface could be occurred through a process called the Vroman effect in which some proteins initially adsorbed on the NP surface are subsequently exchanged by other proteins having higher affinity to NP surface over time. 18 In some cases, proteins adsorbed on the NPs prevent the adsorption of some proteins through a competitive protein adsorption process.…”

Section: Introductionmentioning

confidence: 99%

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