Identification of the perturbed metabolic pathways associating with prostate cancer cells and anticancer affects of obacunone

Untargeted metabolomics using liquid chromatography coupled with mass spectrometry for rapid discovery of metabolite biomarkers to reveal therapeutic effects ofPsoralea corylifoliaseeds against osteoporosis

“…Metabolomics method has demonstrated potential in some elds such as toxicology, [49][50][51][52][53][54][55] nutrition, [56][57][58][59][60][61] genetic manipulation, [62][63][64][65][66][67] cancer, [68][69][70][71][72] diabetes, [73][74][75][76][77][78][79][80][81] environment, [82][83][84][85][86][87][88][89] disease diagnosis 90 and drug discovery and research. [91][92][93][94][95][96][97][98] Liquid chromatography coupled with mass spectrometry has been used as powerful tools to di...…”

High-throughput liquid chromatography mass-spectrometry-driven lipidomics discover metabolic biomarkers and pathways as promising targets to reveal the therapeutic effects of the Shenqi pill

“…[24][25][26][27][28][29][30][31][32] MS is a sensitive, efficient and high throughput method of medicine development, which can provide especially useful structural information for medicine analysis. [33][34][35][36][37][38][39][40][41] In recent years, exponential growth in the application of MS in lipidomics, and separation technology based on MS also got remarkable progress. [42][43][44][45][46][47][48][49][50][51][52][53] It has enabled the discovery of potential biomarkers and explore disease pathogenesis, [54][55][56][57][58][59][60][61][62][63][64] disease diagnosis, [65][66][67][68][69][70][71] prognosis, [72]<...>…”

Characterization of chemical constituents and absorbed components, screening the active components of gelanxinning capsule and an evaluation of therapeutic effects by ultra‐high performance liquid chromatography with quadrupole time of flight mass spectrometry

“…A large amount of information bringing about by metabolomics indicated that these approaches will open a new perspective on disease processes and eventually transit from theory to clinical applications [65][66][67][68][69][70]. Scientists hope metabolomics will help detect disease early with distinctive metabolite data by higher analytical sensitivity of metabolomics techniques [71][72][73][74][75][76]. Accurate identification of metabolites and integration of metabolomics-based diagnostic principles into CHD might be a future challenge to the revolution of health care, which needs a lot of time and work, and so far make researchers feel difficult in the exploring road.…”