Identification of the orphan GPR25 as a receptor of the chemokine CXCL17
Wen-Feng Hu,
Jie Yu,
Juan-Juan Wang
et al.
Abstract:C-X-C motif chemokine ligand 17 (CXCL17) is a small secretory protein primarily expressed in mucosal tissues and likely functions as a chemoattractant, but its receptor is still controversial. In the present study, we identified the rarely studied orphan G protein-coupled receptor 25 (GPR25) as a receptor of CXCL17 via prediction by the newly developed AlphaFold 3 algorithm and validation by the NanoBiT-based beta-arrestin recruitment assay. In the beta-arrestin recruitment assay, recombinant human CXCL17 coul… Show more
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