Identification of the modulatory Ca
2+
-binding sites of acid-sensing ion channel 1a
Ophélie Molton,
Olivier Bignucolo,
Stephan Kellenberger
Abstract:Acid-sensing ion channels (ASICs) are neuronal Na
+
-permeable ion channels activated by extracellular acidification. ASICs are involved in learning, fear sensing, pain sensation and neurodegeneration. Increasing the extracellular Ca
2+
concentration decreases the H
+
sensitivity of ASIC1a, suggesting a competition for binding sites between H
+
and Ca
2+
ions. Here, we predicted candidate res… Show more
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