Identification of the Main Metabolites of a Marine-Derived Strain of Penicillium brevicompactum Using LC and GC MS Techniques

Abstract

Marine-derived fungi are an important source of many valuable compounds with original structures and diverse physico-chemical properties. In this work, the metabolomic profile of a strain of Penicillium brevicompactum, recovered from a snakelocks sea anemone (Anemonia sulcata), was investigated through the parallel application of LC-ESI-HRMS, GC-MS, and NMR. Our strategy allowed the identification of mycophenolic acid, brevianamide A, and several compounds belonging to the thiosilvatins. Among the latter, five products are reported for the first time in this species. The main product of this series, cis-bis(methylthio)silvatin, was also tested for antiproliferative activity on both cancer and non-tumoral colon cell lines.

Anti-Insect Properties of Penicillium Secondary Metabolites

“…Penicillium species (Eurotiomycetes, Aspergillaceae) are widespread in every environment on earth, from desert sands to Antarctica to ocean trenches [ 8 , 12 , 13 , 14 ]. Their occurrence in ecosystems is even more pervasive as a result of the ability to establish symbiotic relationships with various organisms [ 11 , 15 , 16 ].…”

Editorial: Designing Bio-Formulations Based on Organic Amendments, Beneficial Microbes and Their Metabolites

“…Marine-derived fungi are considered good producers of valuable compounds with original structures and interesting biochemical properties that can be exploited for new drug discovery (Silber et al, 2016 ; Nicoletti and Vinale, 2018 ; Vinale et al, 2020 ). Zhao et al isolated two novel fusarisetins, namely fusarisetins C and D, and four known compounds produced by the fungus Fusarium equiseti D39.…”

Rapid detection and identification of dioscorine compounds in Dioscorea hispida tuber plants by LC-ESI-MS

“…An early example of chromatography research includes determining the best resolution of qualifying and quantifying substances. However, the chromatography process can be tough for simultaneous multiple analyses (Vinale et al 2020). Twenty cohort study analyses examined the relationship between mass spectrometry (MS), which uses strongly sensitive identification techniques, and the ionization of sample components using multiple methods (Jalal et al 2018).…”