Identification of the Main Immunogenic Region of Retinal S-Antigen: Subordinate Influence of MHC, IGH, Species or Strain Differences on the Specificity of the Antibody Response
Abstract:The factors which lead to selection of dominant antigenic sites concentrated in discreet regions of proteins and polypeptides are important to the development of antigen-specific immunotherapies for autoimmune diseases and for vaccine design. In this study, the main immunogenic regions of the immunopathogenic autoantigen, retinal S-antigen, have been identified by examination of the specificity of antibody responses of different species. Using cyanogen bromide and synthetic peptides in western blots and the EL… Show more
“…[7][8][9][10][11][12][13][14][15][16] The clinical and histopathological features of EAU induced by both of these proteins and by their synthetic pathogenic peptides are very similar and bear a close resemblance to endogenous clinical uveitis in humans.17 EAU thus serves as an excellent animal model for clinical uveitis. Considerable information on the immunopatho genesis and pathology of autoimmune uveitis has been obtained using this model.…”
“…[7][8][9][10][11][12][13][14][15][16] The clinical and histopathological features of EAU induced by both of these proteins and by their synthetic pathogenic peptides are very similar and bear a close resemblance to endogenous clinical uveitis in humans.17 EAU thus serves as an excellent animal model for clinical uveitis. Considerable information on the immunopatho genesis and pathology of autoimmune uveitis has been obtained using this model.…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.