Identification of the Glycation Site of Lens γB-Crystallin by Fast Atom Bombardment Tandem Mass Spectrometry

Smith, Jean B.; Hanson, Stacy R.A.; Cerny, Ronald L.; Zhao, Huiren; Abraham, E.C.

doi:10.1006/abio.1996.0501

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Cited by 7 publications

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“…Our data showed that L-and Q-crystallins were susceptible to glycation by fructose, and Zhao et al [16] showed the sites of glycation in L-crystallin by fructose. Although Pennington et al [17] and Smith et al [18] reported the sites of glycation in Q-crystallin by fructose, we further investigated the Q-crystallin situation.…”

Section: Discussionmentioning

confidence: 99%

Specific detections of the early process of the glycation reaction by fructose and glucose in diabetic rat lens

et al. 1998

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The glycation reaction by fructose, as well as that by glucose, in control and diabetic rat lens was analyzed by using antibodies which specifically recognize adducts of lysine with fructose and with glucose. Levels of fructose adducts in diabetic rat lens were 2.5 times that of the control, and correlated with sorbitol levels. This was mainly due to enhanced glycation of L Land Q Q-crystallins by fructose under diabetic conditions. These data suggest that glycation by fructose may also play a role in cataract formation under conditions of diabetes and aging.z 1998 Federation of European Biochemical Societies.

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Section: Discussionmentioning

confidence: 99%