volume 40, issue 4, P379-386 2012
DOI: 10.1016/j.jcms.2011.07.001
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Oliver Seitz, Christoph Schürmann, Josef Pfeilschifter, Stefan Frank, Robert Sader

Abstract: The molecular mechanisms underlying successful myocutaneous skin flap integration, as well as the ischemic loss of transplanted tissue on surgery, remain largely unknown. In this study we used a mouse model of caudally based skin flaps to determine molecular patterns of acute transplant re-integration. Gene chip-based transcriptional analysis revealed an up-regulation of the transcription factor Fra-1 in murine skin flap tissue. Epidermal keratinocytes at the wound margins represented a dominant cellular sourc…

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