Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila

Ida, Takanori; Takahashi, Tomoko; Tominaga, Hatsumi; Sato, Takahiro; Kume, Kazuhiko; Yoshizawa‐Kumagaye, Kumiko; Nishio, Hisahide; Kato, Jun; Murakami, Noboru; Miyazato, Minoru; Kangawa, Kenji; Kojima, Masayasu

doi:10.1016/j.bbrc.2011.09.018

Cited by 37 publications

(19 citation statements)

References 25 publications

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“…2. likely receptor was found, suggesting that Tetranychus does have such a gene. Recently the ligand for the Drosophila GPCR encoded by CG34381 has been identified and called trissin (Ida et al, 2011b). Tetur05g03320 clusters with CG34381 and its Tribolium and Apis orthologs and it is thus the likely ortholog of CG34381, although it is not very similar in sequence to these GPCRs (best BLAST e-value of 4e-64 with Bombyx A31, with CG34381 the e-value is 5e-44).…”

Section: Neuropeptides and Neurohormones Which Were Not Foundmentioning

confidence: 96%

In silico cloning of genes encoding neuropeptides, neurohormones and their putative G-protein coupled receptors in a spider mite

Veenstra

Rombauts

Grbić

2012

Insect Biochemistry and Molecular Biology

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Section: Neuropeptides and Neurohormones Which Were Not Foundmentioning

confidence: 96%

In silico cloning of genes encoding neuropeptides, neurohormones and their putative G-protein coupled receptors in a spider mite

Veenstra

Rombauts

Grbić

2012

Insect Biochemistry and Molecular Biology

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“…However, neuropeptides of a similar size and with six cysteine residues have been identified in other animals. For example, trissin is a 28-residue neuropeptide in D. melanogaster with six cysteine residues that form three intramolecular disulphide bonds [38].…”

Section: Spnp15mentioning

confidence: 99%

The neuropeptide transcriptome of a model echinoderm, the sea urchin Strongylocentrotus purpuratus

Rowe

Elphick

2012

General and Comparative Endocrinology

151

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“…Given the toxic and antimicrobial properties of many Cys containing neuropeptides, one hypothesis is that trissin may have an antimicrobial function. Transcript profiling data for trissin and its receptor on the other hand indicated that transcripts for both were present in the central nervous system of third instar larvae and adults, suggesting that trissin might be a neuropeptide (Ida et al, 2011b). Neuropeptides with high sequence similarity to trissin have been found in several Drosophila species and in three mosquitoes, A. aegypti , A. gambiae , and C. quinquefasciatus as well as in B. mori (Ida et al, 2011b).…”

Section: Deorphanized Neuropeptide Receptorsmentioning

confidence: 99%

“…Transcript profiling data for trissin and its receptor on the other hand indicated that transcripts for both were present in the central nervous system of third instar larvae and adults, suggesting that trissin might be a neuropeptide (Ida et al, 2011b). Neuropeptides with high sequence similarity to trissin have been found in several Drosophila species and in three mosquitoes, A. aegypti , A. gambiae , and C. quinquefasciatus as well as in B. mori (Ida et al, 2011b). In A. mellifera , raalin displayed sequence similarity with trissin but this neuropeptide only features 5 Cys residues (Kaplan et al, 2007).…”

Section: Deorphanized Neuropeptide Receptorsmentioning

confidence: 99%

More than two decades of research on insect neuropeptide GPCRs: an overview

Caers¹,

Verlinden²,

Zels³

et al. 2012

Front. Endocrin.

151

143

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This review focuses on the state of the art on neuropeptide receptors in insects. Most of these receptors are G protein-coupled receptors (GPCRs) and are involved in the regulation of virtually all physiological processes during an insect's life. More than 20 years ago a milestone in invertebrate endocrinology was achieved with the characterization of the first insect neuropeptide receptor, i.e., the Drosophila tachykinin-like receptor. However, it took until the release of the Drosophila genome in 2000 that research on neuropeptide receptors boosted. In the last decade a plethora of genomic information of other insect species also became available, leading to a better insight in the functions and evolution of the neuropeptide signaling systems and their intracellular pathways. It became clear that some of these systems are conserved among all insect species, indicating that they fulfill crucial roles in their physiological processes. Meanwhile, other signaling systems seem to be lost in several insect orders or species, suggesting that their actions were superfluous in those insects, or that other neuropeptides have taken over their functions. It is striking that the deorphanization of neuropeptide GPCRs gets much attention, but the subsequent unraveling of the intracellular pathways they elicit, or their physiological functions are often hardly examined. Especially in insects besides Drosophila this information is scarce if not absent. And although great progress made in characterizing neuropeptide signaling systems, even in Drosophila several predicted neuropeptide receptors remain orphan, awaiting for their endogenous ligand to be determined. The present review gives a précis of the insect neuropeptide receptor research of the last two decades. But it has to be emphasized that the work done so far is only the tip of the iceberg and our comprehensive understanding of these important signaling systems will still increase substantially in the coming years.

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Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila

Cited by 37 publications

References 25 publications

In silico cloning of genes encoding neuropeptides, neurohormones and their putative G-protein coupled receptors in a spider mite

In silico cloning of genes encoding neuropeptides, neurohormones and their putative G-protein coupled receptors in a spider mite

The neuropeptide transcriptome of a model echinoderm, the sea urchin Strongylocentrotus purpuratus

More than two decades of research on insect neuropeptide GPCRs: an overview

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