2021
DOI: 10.2147/ott.s301127
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Identification of the EMT-Related Genes Signature for Predicting Occurrence and Progression in Thyroid Cancer

Abstract: Background:The detection rate of thyroid cancer (TC) has been continuously improved due to the development of detection technology. Epithelial-mesenchymal transition (EMT) is thought to be closely related to the malignant progression of tumors. However, the relationship between EMT-related genes (ERGs) characteristics and the diagnosis and prognosis of TC patients has not been studied. Methods: Four datasets from Gene Expression Omnibus (GEO) were used to perform transcriptomic profile analysis. The overlappin… Show more

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Cited by 5 publications
(4 citation statements)
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References 78 publications
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“…Similarly, patients in the low-risk group were more sensitive to chemotherapy. In recent years, in-depth studies have been conducted on ERGs for different immune states of tumors, and a large number of diagnostic and prognostic assessment methods have been identified (20)(21)(22)50).…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, patients in the low-risk group were more sensitive to chemotherapy. In recent years, in-depth studies have been conducted on ERGs for different immune states of tumors, and a large number of diagnostic and prognostic assessment methods have been identified (20)(21)(22)50).…”
Section: Discussionmentioning
confidence: 99%
“…Overactivation of the PI3K-Akt signaling pathway is one of the key pathways for tumor survival, growth, and proliferation, including BRCA (Liu et al 2023). Focal adhesion also participates in all stages of cancer progression, is related to cell invasion and migration, and is critical for cancer cells to maintain their survival and change their local microenvironment (Li et al 2021;Makrilia et al 2009). These functions are all related to cell proliferation and invasion, which is consistent with previous studies (Zhang et al 2023).…”
Section: Discussionmentioning
confidence: 99%
“…Early detection and diagnosis of tumors is helpful for timely medical intervention and greatly improves survival and quality of life. Thyroid cancer is a common malignant endocrine tumor and its incidence is increasing annually [ 13 , 14 ]. Understanding the pathogenesis of thyroid cancer is essential for improving the accuracy of diagnosis, precise risk stratification, and realizing personalized treatment.…”
Section: Discussionmentioning
confidence: 99%