Identification of the elastic properties of an artificial capsule membrane with the compression test: Effect of thickness

Rachik, Mohamed; Barthès-Biesel, Dominique; Carin, Muriel; Edwards-Lévy, Florence

doi:10.1016/j.jcis.2006.04.062

Cited by 76 publications

(71 citation statements)

References 35 publications

(74 reference statements)

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“…For biological membranes, the factor C is usually much larger than unity, because of their quasi area incompressibility. In the case of artificial capsules, the SK law has been found to fit experimental data when values of order 1 are used for the factor C (Carin et al 2003;Risso & Carin 2004;Rachik et al 2006). In the present study, the simulations are conducted for capsules enclosed by an SK membrane with C = 1, unless otherwise stated.…”

Section: Problem Descriptionmentioning

confidence: 99%

Motion of a spherical capsule in branched tube flow with finite inertia

et al. 2016

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We computationally study the transient motion of an initially spherical capsule flowing through a right-angled tube bifurcation, composed of tubes having the same diameter. The capsule motion and deformation is simulated using a three-dimensional immersed-boundary lattice Boltzmann method. The capsule is modelled as a liquid droplet enclosed by a hyperelastic membrane following the Skalak's law (Skalak et al., Biophys. J., vol. 13(3), 1973, pp. 245-264). The fluids inside and outside the capsule are assumed to have identical viscosity and density. We mainly focus on path selection of the capsule at the bifurcation as a function of the parameters of the problem: the flow split ratio, the background flow Reynolds number Re, the capsule-to-tube size ratio a/R and the capillary number Ca, which compares the viscous fluid force acting on the capsule to the membrane elastic force. For fixed physical properties of the capsule and of the tube flow, the ratio Ca/Re is constant. Two size ratios are considered: a/R = 0.2 and 0.4. At low Re, the capsule favours the branch which receives most flow. Inertia significantly affects the background flow in the branched tube. As a consequence, at equal flow split, a capsule tends to flow straight into the main branch as Re is increased. Under significant inertial effects, the capsule can flow into the downstream main tube even when it receives much less flow than the side branch. Increasing Ca promotes cross-stream migration of the capsule towards the side branch. The results are summarized in a phase diagram, showing the critical flow split ratio for which the capsule flows into the side branch as a function of size ratio, Re and Ca/Re. We also provide a simplified model of the path selection of a slightly deformed capsule and explore its limits of validity. We finally discuss the experimental feasibility of the flow system and its applicability to capsule sorting.

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Section: Problem Descriptionmentioning

confidence: 99%

Motion of a spherical capsule in branched tube flow with finite inertia

et al. 2016

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“…The surface of the shells is highly porous, with pore diameters in the range of 1 -10 mm. The porosity in the shell and the lack of an internal structure makes these capsules mechanically fragile, and results in deformed shells (Rachik et al 2006). The shell has a thickness of 5 -10 mm, as can be seen in the broken capsule in figure 9b.…”

mentioning

confidence: 99%

“…Finally, it should be stressed that by varying the processing conditions it is possible to modify the shell thickness of solid and porous capsules; this, in turn, results in changes in their mechanical and release behaviour (Rachik et al 2006), as well as in the volume fraction of 'cargo' that they can accommodate in their central cavity. …”

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confidence: 99%

Ceramic microparticles and capsules via microfluidic processing of a preceramic polymer

Chen

Colombo

et al. 2010

J. R. Soc. Interface.

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We have developed a robust technique to fabricate monodispersed solid and porous ceramic particles and capsules from single and double emulsion drops composed of silsesquioxane preceramic polymer. A microcapillary microfluidic device was used to generate the monodispersed drops. In this device, two round capillaries are aligned facing each other inside a square capillary. Three fluids are needed to generate the double emulsions. The inner fluid, which flows through the input capillary, and the middle fluid, which flows through the void space between the square and inner fluid capillaries, form a coaxial co-flow in a direction that is opposite to the flow of the outer fluid. As the three fluids are forced through the exit capillary, the inner and middle fluids break into monodispersed double emulsion drops in a single-step process, at rates of up to 2000 drops s 21. Once the drops are generated, the silsesquioxane is cross-linked in solution and the cross-linked particles are dried and pyrolysed in an inert atmosphere to form oxycarbide glass particles. Particles with diameters ranging from 30 to 180 mm, shell thicknesses ranging from 10 to 50 mm and shell pore diameters ranging from 1 to 10 mm were easily prepared by changing fluid flow rates, device dimensions and fluid composition. The produced particles and capsules can be used in their polymeric state or pyrolysed to ceramic. This technique can be extended to other preceramic polymers and can be used to generate unique core -shell multimaterial particles.

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“…Figura 23 -Variação da espessura da membrana As propriedades mecânicas de micropartículas são comumente caracterizadas através de métodos de confinamento e compressão simples (Rachik et al, 2006;Vilanova et al, 2013;Duncanson et al, 2014). Para caracterizar mecanicamente as microcápsulas, são realizados testes de compressão e relaxamento para partículas simples, ou seja, as microcápsulas são submergidas em água e colocadas entre duas placas paralelas em um reômetro.…”

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Visualização Tridimensional Do Deslocamento De Óleo Por Suspensões De Microcápsulas Flexíveis Em Meios Porosos

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Identification of the elastic properties of an artificial capsule membrane with the compression test: Effect of thickness

Cited by 76 publications

References 35 publications

Motion of a spherical capsule in branched tube flow with finite inertia

Motion of a spherical capsule in branched tube flow with finite inertia

Ceramic microparticles and capsules via microfluidic processing of a preceramic polymer

Visualização Tridimensional Do Deslocamento De Óleo Por Suspensões De Microcápsulas Flexíveis Em Meios Porosos

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