Identification of the degradation products of a crosslinked polyester using LC-MS

Tapia, Jesús B.; Haines, Jason; Yapor, Janet P.; Reynolds, Melissa M.

doi:10.1016/j.polymdegradstab.2019.108948

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…The degradation products of crosslinked polyester have been separated and identified by LC−MS over a 10-week incubation. 269 Seven major chromatographic peaks could be observed from the LC graph. The extracted mass spectra showed that the peak at 5.07 min corresponded to m/z 265, matching the [M − H] − ion for C 8 H 10 O 8 S. The peaks at 12.39 and 15.85 min were ascribed to m/z 393 of C 16 H 26 O 9 S. Moreover, the aging of poly(ester-urethane-urea) has been implemented in abiotic aqueous and in soil for 57 days, and the amino, alcohol, and carboxylic acid fragments have been identified from the cleavage of ester and urea linkages.…”

Section: Mass Spectroscopy To Evaluate Low-molecular Productsmentioning

confidence: 99%

See 1 more Smart Citation

Characterization Techniques of Polymer Aging: From Beginning to End

Tian

Lin

et al. 2023

Chem. Rev.

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Polymers have been widely applied in various fields in the daily routines and the manufacturing. Despite the awareness of the aggressive and inevitable aging for the polymers, it still remains a challenge to choose an appropriate characterization strategy for evaluating the aging behaviors. The difficulties lie in the fact that the polymer features from the different aging stages require different characterization methods. In this review, we present an overview of the characterization strategies preferable for the initial, accelerated, and late stages during polymer aging. The optimum strategies have been discussed to characterize the generation of radicals, variation of functional groups, substantial chain scission, formation of low-molecular products, and deterioration in the polymers' macro-performances. In view of the advantages and the limitations of these characterization techniques, their utilization in a strategic approach is considered. In addition, we highlight the structure−property relationship for the aged polymers and provide available guidance for lifetime prediction. This review could allow the readers to be knowledgeable of the features for the polymers in the different aging stages and provide access to choose the optimum characterization techniques. We believe that this review will attract the communities dedicated to materials science and chemistry.

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Section: Mass Spectroscopy To Evaluate Low-molecular Productsmentioning

confidence: 99%

“…LC–MS has been widely applied for the biodegradable polyesters. The degradation products of cross-linked polyester have been separated and identified by LC–MS over a 10-week incubation . Seven major chromatographic peaks could be observed from the LC graph.…”

Section: Characterization For Generation Of Low-molecular Productsmentioning

confidence: 99%

Characterization Techniques of Polymer Aging: From Beginning to End

Tian

Lin

et al. 2023

Chem. Rev.

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“…Sample preparation is comparatively easy, and it has the ability to recognize and measure a wider range of compounds (Perez et al, 2016). Tapia et al (2019) recently used LC-MS and developed a method for identifying the degradation compounds of a cross-linked polyester for biomedical relevance (Tapia et al, 2019). They used both LC-MS and LC-MS/MS for characterizing structural isomers and their corresponding structures.…”

Section: Characterization Techniques For Produced By-productsmentioning

confidence: 99%

Recent Advances in Photocatalytic Removal of Microplastics: Mechanisms, Kinetic Degradation, and Reactor Design

Hamd

Daher

Tofa³

et al. 2022

Front. Mar. Sci.

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Plastic products are used in almost all aspects of our daily life. Due to their low cost, portability, durability, and resistance to degradation, these products are affecting the health of the environment and biota on a global scale. Thus, the removal and mineralization of microplastics is an important challenge in the 21st century. Advanced oxidation processes (AOPs) have recently been identified as a viable treatment technique for tackling recalcitrant organic molecules and polymers. However, information on kinetic degradation mechanisms and photocatalytic reactor design is insufficient. This review discusses the fundamentals of photocatalysis and photo-Fenton processes in addition to the photocatalytic degradation mechanisms. We also introduce different characterization techniques of the major microplastic pollutants such as PE, PP, PVC, PS, PMMA, and PA66. In addition, a detailed overview of the major existing photocatalytic plants and the scaling-up methods of photoreactors are discussed.

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“…Reports describing the use of in silico modeling to achieve spectral interpretation (improve candidate identifications) for medical device extractables studies could not be found. However, in silico modeling may be used to model fragmentation as a means to determine polymer degradation products…”

Section: Chemical Analysismentioning

confidence: 99%

“…244 Reports describing the use of in silico modeling to achieve spectral interpretation (improve candidate identifications) for medical device extractables studies could not be found. However, in silico modeling may be used to model fragmentation as a means to determine polymer degradation products 245 Evaluating Identification Performance. Identification performance can be challenging to evaluate since match scores do not describe the statistical accuracy of the assignment.…”

Section: ■ Extractionmentioning

confidence: 99%

Chemical Characterization and Non-targeted Analysis of Medical Device Extracts: A Review of Current Approaches, Gaps, and Emerging Practices

Sussman

Öktem

Isayeva

et al. 2022

ACS Biomater. Sci. Eng.

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The developers of medical devices evaluate the biocompatibility of their device prior to FDA’s review and subsequent introduction to the market. Chemical characterization, described in ISO 10993-18:2020, can generate information for toxicological risk assessment and is an alternative approach for addressing some biocompatibility end points (e.g., systemic toxicity, genotoxicity, carcinogenicity, reproductive/developmental toxicity) that can reduce the time and cost of testing and the need for animal testing. Additionally, chemical characterization can be used to determine whether modifications to the materials and manufacturing processes alter the chemistry of a patient-contacting device to an extent that could impact device safety. Extractables testing is one approach to chemical characterization that employs combinations of non-targeted analysis, non-targeted screening, and/or targeted analysis to establish the identities and quantities of the various chemical constituents that can be released from a device. Due to the difficulty in obtaining a priori information on all the constituents in finished devices, information generation strategies in the form of analytical chemistry testing are often used. Identified and quantified extractables are then assessed using toxicological risk assessment approaches to determine if reported quantities are sufficiently low to overcome the need for further chemical analysis, biological evaluation of select end points, or risk control. For extractables studies to be useful as a screening tool, comprehensive and reliable non-targeted methods are needed. Although non-targeted methods have been adopted by many laboratories, they are laboratory-specific and require expensive analytical instruments and advanced technical expertise to perform. In this Perspective, we describe the elements of extractables studies and provide an overview of the current practices, identified gaps, and emerging practices that may be adopted on a wider scale in the future. This Perspective is outlined according to the steps of an extractables study: information gathering, extraction, extract sample processing, system selection, qualification, quantification, and identification.

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Identification of the degradation products of a crosslinked polyester using LC-MS

Cited by 4 publications

References 17 publications

Characterization Techniques of Polymer Aging: From Beginning to End

Characterization Techniques of Polymer Aging: From Beginning to End

Recent Advances in Photocatalytic Removal of Microplastics: Mechanisms, Kinetic Degradation, and Reactor Design

Chemical Characterization and Non-targeted Analysis of Medical Device Extracts: A Review of Current Approaches, Gaps, and Emerging Practices

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