Identification of the C-terminal tail domain of AHF/trichohyalin as the critical site for modulation of the keratin filamentous meshwork in the keratinocyte

Takase, Takahisa; Hirai, Yohei

doi:10.1016/j.jdermsci.2011.12.014

Cited by 12 publications

(14 citation statements)

References 27 publications

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“…Genes located between the SFTP genes and S100A11 in X. laevis do not have homologs at syntenic positions in the genomes of amniotes ( Figure 1A). Of note, peptidoglycan recognition protein genes and loricrin-like genes, which are present in the epidermal differentiation complex (EDC) regions of humans and other amniotes, [17] are absent in the vicinity of frog SFTP genes.…”

Section: Resultsmentioning

confidence: 99%

“…The latter sequence motif (core sequence: SPLy(E/D)y) has been implicated in the interaction of SFTPs with keratin filaments. [14,17,23] The identification of sequence elements, such as the S100 domain and the carboxy-terminal motif, that are conserved in SFTPs of phylogenetically most diverse tetrapods indicates that these features were already present in evolutionarily ancient SFTPs and may help to define the functions of SFTP domains in future experimental studies.…”

Section: Resultsmentioning

confidence: 99%

“…[14][15][16] However, the evolutionary origin of SFTPs has remained uncertain because of incomplete genome data of the next relatives of amniotes, the amphibians. Here, we performed a comparative genomics study to infer the time of origin of SFTPs and to estimate when sequence elements of SFTPs, such as the carboxy-terminal motif implicated in binding keratin filaments, [14,17] have evolved.…”

Section: Questions Addressedmentioning

confidence: 99%

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Filaggrin has evolved from an “S100 fused‐type protein” (SFTP) gene present in a common ancestor of amphibians and mammals

Mlitz

Hussain

Tschachler

et al. 2017

Experimental Dermatology

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The expression of filaggrin in differentiated keratinocytes and the association of filaggrin mutations with ichthyosis vulgaris and atopic dermatitis suggest that this prototypical member of the S100 fusedtype protein (SFTP) family plays a key role in the epidermal barrier to the environment. Here, we report that SFTP genes are present not only in amniotes but also in amphibians. Four SFTPs are expressed in the skin of the frog Xenopus laevis. The results of this study indicate that filaggrin has evolved from an ancestral SFTP that may have contributed to skin modifications during the evolutionary transition to terrestrial life.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Questions Addressedmentioning

confidence: 99%

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Filaggrin has evolved from an “S100 fused‐type protein” (SFTP) gene present in a common ancestor of amphibians and mammals

Mlitz

Hussain

Tschachler

et al. 2017

Experimental Dermatology

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“…‘//’ indicates sequence gaps that were introduced to facilitate the depiction of all sequence ends. The sequence motif of trichohyalin that was investigated by Takase and Hirai ( 41 ) is underlined. The consensus sequence of the ancestral carboxy-terminal motif of SFTPs is shown below the alignment.…”

Section: Resultsmentioning

confidence: 99%

Comparative genomics reveals conservation of filaggrin and loss of caspase‐14 in dolphins

Strasser

Mlitz

Fischer

et al. 2015

Experimental Dermatology

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The expression of filaggrin and its stepwise proteolytic degradation are critical events in the terminal differentiation of epidermal keratinocytes and in the formation of the skin barrier to the environment. Here, we investigated whether the evolutionary transition from a terrestrial to a fully aquatic lifestyle of cetaceans, that is dolphins and whales, has been associated with changes in genes encoding filaggrin and proteins involved in the processing of filaggrin. We used comparative genomics, PCRs and re-sequencing of gene segments to screen for the presence and integrity of genes coding for filaggrin and proteases implicated in the maturation of (pro)filaggrin. Filaggrin has been conserved in dolphins (bottlenose dolphin, orca and baiji) but has been lost in whales (sperm whale and minke whale). All other S100 fused-type genes have been lost in cetaceans. Among filaggrin-processing proteases, aspartic peptidase retroviral-like 1 (ASPRV1), also known as saspase, has been conserved, whereas caspase-14 has been lost in all cetaceans investigated. In conclusion, our results suggest that filaggrin is dispensable for the acquisition of fully aquatic lifestyles of whales, whereas it appears to confer an evolutionary advantage to dolphins. The discordant evolution of filaggrin, saspase and caspase-14 in cetaceans indicates that the biological roles of these proteins are not strictly interdependent.

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“…Recently, the C-terminal 13 amino acid sequence in the tail domain 9, which is conserved among species, was shown to be essential for keratin adherent ability of mouse TCHH in keratinocyte cell lines, though neither deimination nor isopeptide cross-links within the functionally critical sites has yet been determined. Based on these observations, Takase and Hirai ( 2012 ) proposed a principal role of the C-terminal tail domain of TCHH in adhesion to keratins. Following aggregation of N-terminal parts (i.e., N-terminal S100-like domain and following repetitive peptide domains) in TCHH, KIFs bundle and form meshes.…”

Section: Cit-tchh Susceptibility To Transglutaminasementioning

confidence: 99%

Importance of Citrullination on Hair Protein Molecular Assembly During Trichocytic Differentiation

Kizawa¹,

Unno

Heizmann

et al. 2013

Protein Deimination in Human Health and Disease

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Identification of the C-terminal tail domain of AHF/trichohyalin as the critical site for modulation of the keratin filamentous meshwork in the keratinocyte

Cited by 12 publications

References 27 publications

Filaggrin has evolved from an “S100 fused‐type protein” (SFTP) gene present in a common ancestor of amphibians and mammals

Filaggrin has evolved from an “S100 fused‐type protein” (SFTP) gene present in a common ancestor of amphibians and mammals

Comparative genomics reveals conservation of filaggrin and loss of caspase‐14 in dolphins

Importance of Citrullination on Hair Protein Molecular Assembly During Trichocytic Differentiation

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