Identification of the anterior corticospinal tract in the human brain using diffusion tensor imaging

Kwon, Hyeok Gyu; Lee, Dong Gyu; Son, Su Min; Byun, Woo Mok; Hong, Cheol Pyo; Lee, Dong Hoon; Kim, Saeyoon; Jang, Sung Ho

doi:10.1016/j.neulet.2011.10.020

Cited by 11 publications

(14 citation statements)

References 32 publications

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“…As shown in Figure 2, the manual fibers are in lateral aspects of the cerebral peduncle while the oral fibers are more medial. This organization and structure of the motor control fiber pathways agree with previous work with DTI and fMRI, showing a preservation of somatotopic organization in the motor control system from the motor cortex to the cerebral peduncle (Guye et al, 2003; Hong, Son, Jang 2010; Kamada et al, 2005; Kwon et al, 2011; Park et al, 2008; Park et al, 2008; Virta, Barnett, Pierpaoli 1999). …”

Section: Discussionsupporting

confidence: 90%

Investigating Age-related changes in fine motor control across different effectors and the impact of white matter integrity

et al. 2014

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Changes in fine motor control that eventually compromise dexterity accompany advanced age; however there is evidence that age-related decline in motor control may not be uniform across effectors. Particularly, the role of central mechanisms in effector-specific decline has not been examined but is relevant for placing age-related motor declines into the growing literature of age-related changes in brain function. We examined sub-maximal force control across three different effectors (fingers, lips, and tongue) in 18 young and 14 older adults. In parallel with the force variability measures we examined changes in white matter structural integrity in effector-specific pathways in the brain with diffusion tensor imaging (DTI). Motor pathways for each effector were identified by using an fMRI localizer task followed by tractography to identify the fiber tracts propagating to the midbrain. Increases in force control variability were found with age in all three effectors but the effectors showed different degrees of age-related variability. Motor control changes were accompanied by a decline in white matter structural integrity with age shown by measures of fractional anisotropy and radial diffusivity. The DTI metrics appear to mediate some of the age-related declines in motor control. Our findings indicate that the structural integrity of descending motor systems may play a significant role in age-related increases in motor performance variability, but that differential age-related declines in oral and manual effectors are not likely due to structural integrity of descending motor pathways in the brain.

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Section: Discussionsupporting

confidence: 90%

Investigating Age-related changes in fine motor control across different effectors and the impact of white matter integrity

et al. 2014

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“…Future studies separating fibers that cross vs. those which do not cross in the medulla can further address this issue; feasibility of such separation by DTI tractography has been demonstrated recently. 24 …”

Section: Discussionmentioning

confidence: 99%

Patterns of Structural Reorganization of the Corticospinal Tract in Children With Sturge-Weber Syndrome

Kamson

Juhász

Shin

et al. 2014

Pediatric Neurology

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Background Reorganization of the corticospinal tract (CST) after early damage can limit motor deficit. In this study, we explored patterns of structural CST reorganization in children with Sturge-Weber syndrome. Methods Five children (age 1.5-7 years) with motor deficit due to unilateral Sturge-Weber syndrome were studied prospectively and longitudinally (1-2 years follow-up). CST segments belonging to hand and leg movements were separated, and their volume was measured by diffusion tensor imaging (DTI) tractography using a recently validated method. CST segmental volumes were normalized and compared between the SWS children and age-matched healthy controls. Volume changes during follow-up were also compared to clinical motor symptoms. Results In the SWS children, hand-related (but not leg-related) CST volumes were consistently decreased in the affected cerebral hemisphere at baseline. At follow-up, two distinct patterns of hand CST volume changes emerged: (i) Two children with extensive frontal lobe damage showed a CST volume decrease in the lesional hemisphere and a concomitant increase in the non-lesional (contralateral) hemisphere. These children developed good hand grasp but no fine motor skills. (ii) The three other children, with relative sparing of the frontal lobe, showed an interval increase of the normalized hand CST volume in the affected hemisphere; these children showed no gross motor deficit at follow-up. Conclusions DTI tractography can detect differential abnormalities in the hand CST segment both ipsi- and contralateral to the lesion. Interval increase in the CST hand segment suggests structural reorganization, whose pattern may determine clinical motor outcome and could guide strategies for early motor intervention.

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“…However, no optimal degree of tract turning angle has been reported; instead, TCMF tends to be easily changed by the tract turning angle (Lee et al, 2005). Therefore, we reconstructed the CST using the FA value of 0.2 and compared the incidence of TCMF using three different tract turning angles (45, 60, and 75°), which have been adopted popularly in other studies using DTT for the CST (Jang et al, 2009; Son et al, 2009; Kwon et al, 2011). …”

Section: Discussionmentioning

confidence: 99%

Development of the transcallosal motor fiber from the corticospinal tract in the human brain: diffusion tensor imaging study

Kwon

Son

Jang

2014

Front. Hum. Neurosci.

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Transcallosal motor fiber (TCMF) plays a role in interhemispheric inhibition (IHI) between two primary motor cortices. IHI has been an important concept in development of the motor system of the brain. Many studies have focused on the research of the topography of TCMF, however, little is known about development of TCMF. In the current study, we attempted to investigate development of TCMF from the corticospinal tract (CST) in the human brain using diffusion tensor tractography. A total of 76 healthy subjects were recruited for this study. We reconstructed the TCMF, which was derived from the CST, by selection of two regions of interest below the corpus callosum (upper and middle pons). Termination criteria used for fiber tracking were fractional anisotropy <0.2 and three tract turning angles of <45, 60, and 75°. The subjects were classified into four groups according to age: group A (0–5 years), group B (6–10 years), group C (11–15 years), and group D (16–20 years). Significant differences in the incidence of TCMF were observed between group B and group C, and between group B and group D, with tract turning angles of 60 and 75° (p < 0.05). However, no significant differences in any tract turning angle were observed between group C and group D (p > 0.05). In addition, in terms of the incidence of TCMF, no significant differences were observed between the three tract turning angles (p > 0.05). We obtained visualized TCMF from the CST with development and found that the incidence of TCMF differed significantly around the approximate age of 10 years. As a result, we demonstrated structural evidence for development of TCMF in the human brain.

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Identification of the anterior corticospinal tract in the human brain using diffusion tensor imaging

Cited by 11 publications

References 32 publications

Investigating Age-related changes in fine motor control across different effectors and the impact of white matter integrity

Investigating Age-related changes in fine motor control across different effectors and the impact of white matter integrity

Patterns of Structural Reorganization of the Corticospinal Tract in Children With Sturge-Weber Syndrome

Development of the transcallosal motor fiber from the corticospinal tract in the human brain: diffusion tensor imaging study

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