Identification of thaumatin‐like protein and aspartyl protease as new major allergens in lettuce (<i><scp>L</scp>actuca sativa</i>)

Muñoz-García, Esther; Luengo, Olga; Haroun‐Díaz, Elisa; Maroto, Aroa S.; Palacín, Arantxa; Perales, Araceli Diaz; Gozalo, Manuel de las Heras; Labrador‐Horrillo, Moisés; Vivanco, Fernando; Cuesta‐Herranz, Javier; Pastor-Vargas, Carlos

doi:10.1002/mnfr.201300139

Cited by 16 publications

(18 citation statements)

References 33 publications

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“…Lettuce LTP was found to be the major allergen in our series, supporting previous reports [13]. However, while this LTP was recognized in 80% of lettuce-allergic patients, peach LTP was recognized in an even higher proportion and Abbreviations: CEFA, cofactor-enhanced food allergy; NSAID, nonsteroidal anti-inflammatory drug.…”

Section: Discussionsupporting

confidence: 90%

“…Specific IgE to Lac s 1 (lettuce LTP) had been qualitatively assessed by means of immunoblotting and mass spectrometry analysis in a previous study by our group [13].…”

Section: Methodsmentioning

confidence: 99%

“…Although lettuce is one of the most frequent offending foods related to LTP syndrome, little is known about the peculiarities of lettuce allergy, as there have been few case reports and only 3 cases series have been described to date [11][12][13]. The aim of this study was to define the clinical characteristics of lettuce allergy and the frequency of LTP syndrome in a cohort of lettuce-allergic patients.…”

Section: Introductionmentioning

confidence: 99%

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Lettuce Allergy Is a Lipid Transfer Syndrome-Related Food Allergy With a High Risk of Severe Reactions

Muñoz-García¹,

Luengo²,

Moreno-Pérez³

et al. 2017

J Investig Allergol Clin Immunol

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Background and Objectives: Lipid transfer protein (LTP) sensitization is the most common cause of food allergy in the Mediterranean area, with peach allergy acting as the primary sensitizer in most cases. Lettuce has been described as a common offending food in patients with LTP syndrome. The aim of the study was to investigate the frequency and clinical expression of LTP syndrome in a sample of lettuceallergic patients. Methods: We determined specific IgE to Pru p 3 and lettuce in a sample of 30 patients with a diagnosis of lettuce allergy. Symptoms elicited by other LTP-containing plant-derived foods and the presence of cofactors were assessed. Results: The clinical symptoms of lettuce allergy were frequently severe, with 18 of the 30 patients experiencing anaphylaxis. All the patients had allergic reactions to other plant foods. Cofactors were involved in the clinical reactions of 13 of the 30 patients. Sensitization to pollens was found in 90% of patients. Conclusions: Lettuce allergy is found not as an isolated condition but in the context of LTP syndrome and it is characterized by severe reactions and frequent cofactor association.

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Section: Discussionsupporting

confidence: 90%

“…Specific IgE to Lac s 1 (lettuce LTP) had been qualitatively assessed by means of immunoblotting and mass spectrometry analysis in a previous study by our group [13].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lettuce Allergy Is a Lipid Transfer Syndrome-Related Food Allergy With a High Risk of Severe Reactions

Muñoz-García¹,

Luengo²,

Moreno-Pérez³

et al. 2017

J Investig Allergol Clin Immunol

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“…LTP has been identified as the cause of IgE-mediated anaphylaxis and hypersensitivity in two studies of lettuce allergy via ingestion (Bascones et al, 2009;San Miguel-Moncín et al, 2003). Another allergen that could be involved in pollen-food syndrome is the thaumatin-like protein (TLP), which has also been identified as an allergen in lettuce (Munoz-Garcia et al, 2013).…”

Section: Evidence For Stevia Plant Constituent Allergensmentioning

confidence: 97%

Steviol glycoside safety: Are highly purified steviol glycoside sweeteners food allergens?

Urban

Carakostas

Taylor

2015

Food and Chemical Toxicology

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“…There was no information on atopic diathesis for either of the patients . Of course, it is possible that the patch test gave a negative result because of poor quality of the lettuce used for testing, but another possibility is that the immediate allergy, which is caused by proteinaceous allergens, presented as dermatitis or exacerbated a pre‐existing dermatitis . On the other hand, Oliwiecki et al.…”

Section: Diagnosismentioning

confidence: 99%

Lettuce contact allergy

Paulsen

Andersen

2015

Contact Dermatitis

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SummaryLettuce (Lactuca sativa L.) and its varieties are important vegetable crops worldwide. They are also well-known, rarely reported, causes of contact allergy. As lettuce allergens and extracts are not commercially available, the allergy may be underdiagnosed. The aims of this article are to present new data on lettuce contact allergy and review the literature. Lettuce is weakly allergenic, and occupational cases are mainly reported. Using aimed patch testing in Compositae-allergic patients, two recent Danish studies showed prevalence rates of positive lettuce reactions of 11% and 22%. The majority of cases are non-occupational, and may partly be caused by cross-reactivity. The sesquiterpene lactone mix seems to be a poor screening agent for lettuce contact allergy, as the prevalence of positive reactions is significantly higher in non-occupationally sensitized patients. Because of the easy degradability of lettuce allergens, it is recommended to patch test with freshly cut lettuce stem and supplement this with Compositae mix.

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Identification of thaumatin‐like protein and aspartyl protease as new major allergens in lettuce (Lactuca sativa)

Abstract: Two new major lettuce allergens-a thaumatin-like protein and an aspartyl protease-have been identified and characterized. These allergens may be used to improve both diagnosis and treatment of lettuce-allergic patients.

Cited by 16 publications

References 33 publications

Lettuce Allergy Is a Lipid Transfer Syndrome-Related Food Allergy With a High Risk of Severe Reactions

Lettuce Allergy Is a Lipid Transfer Syndrome-Related Food Allergy With a High Risk of Severe Reactions

Steviol glycoside safety: Are highly purified steviol glycoside sweeteners food allergens?

Lettuce contact allergy

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