Identification of synergistic and antagonistic actions of environmental pollutants: Bisphenols A, S and F in the presence of DEP, DBP, BADGE and BADGE·2HCl in three component mixtures

Jatkowska, Natalia; Kudłak, Błażej; Lewandowska, Patrycja; Li, Wen; Williams, Michael J.; Schiöth, Helgi B.

doi:10.1016/j.scitotenv.2020.144286

Cited by 24 publications

(16 citation statements)

References 38 publications

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“…The researchers unexpectedly observed a strong antagonistic impact with DEP, in mixtures containing BPA and BADGE analogues (also confirmed with mathematical models). This study also showed that the impact of BPS and BPF in many mixtures was highly concentration dependent, justifying the necessity of performing mixture studies using wide concentration ranges (147).…”

Section: In Vivo Studiesmentioning

confidence: 73%

Testicular dysgenesis syndrome and phthalate exposure: A review of literature

Erkekoğlu¹,

Ozyurt²,

Yirün³

et al. 2021

Arhiv za farmaciju

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Endocrine disruptors are chemicals that interfere with the body's endocrine system and cause adverse effects in biological systems. Phthalates are a group of man-made chemicals which are mainly used as plasticizers and classified as endocrine disruptors. They are also used in cosmetic and personal care products as color or smell fixators. Moreover, phthalates are present in inks, adhesives, sealants, automobile parts, tools, toys, carpets, medical tubing and blood storage bags, and food packages. Pathological condition known as "testicular dysgenesis syndrome" (TDS) or "phthalate syndrome" is usually linked to phthalate exposure and is coined to describe the rise in alterations in reproductive health in men, such as reduced semen quality (decrease in sperm counts, sperm motility and increase in abnormal sperms), hypospadias, cryptorchidism, reduced anogenital distance and early-life testicular cancer. Phthalates are suggested to cause direct effect on gonadal and non-gonadal tissues, impair the differentiation and morphogenesis of seminiferous tubules and accessory sex organs and testicular cells (both Sertoli and Leydig cells), alter estradiol and/or testosterone levels, decrease insulin-like 3 (INSL3) peptide production, impair spermatogenesis and lead to epigenetic alterations, all of which may lead to TDS. This review will mainly focus on phthalates as causes of TDS and their mechanisms of action.

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Section: In Vivo Studiesmentioning

confidence: 73%

Testicular dysgenesis syndrome and phthalate exposure: A review of literature

Erkekoğlu¹,

Ozyurt²,

Yirün³

et al. 2021

Arhiv za farmaciju

View full text Add to dashboard Cite

show abstract

“…Thus, due to their omnipresence in the environment, a mixture of EDCs, such as DEHP, DBP, and bisphenol A (BPA), has the capability to induce more pronounced effects than those provoked by single substances. Possible additive effects, including synergistic and antagonistic effects, were reported both in vivo and in vitro [50][51][52][53]. However, this study did not cover a variety of EDCs, and the effects of the mixture need to be clarified by future studies.…”

Section: Discussionmentioning

confidence: 99%

Association of Phthalate Exposure with Thyroid Function and Thyroid Homeostasis Parameters in Type 2 Diabetes

Chen

Zhang

Chen

et al. 2021

Journal of Diabetes Research

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Aims. Phthalates, which are recognized environmental endocrine-disrupting chemicals, are associated with thyroid hormone disruption. We aimed to evaluate the relationship of phthalate metabolites with thyroid function and thyroid homeostasis parameters in type 2 diabetes and to explore whether thyroid autoimmunity status and metformin, the most common antidiabetic drug, may influence such associations. Methods. Concurrent urine and blood samples were collected from 639 participants with type 2 diabetes in the METAL (Environmental Pollutant Exposure and Metabolic Diseases in Shanghai) study. We measured urinary concentrations of thirteen phthalate metabolites along with serum levels of thyroid-stimulating hormone (TSH), total T4 and T3, free T4 (FT4) and T3 (FT3), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb). Four parameters of thyroid homeostasis, including the sum activity of step-up deiodinases (SPINA-GD), thyroid secretory capacity (SPINA-GT), Jostel’s TSH index (TSHI), and thyrotroph thyroid hormone resistance index (TTSI), were also calculated. Results. Among all participants, after full adjustment, multivariable regression analysis showed that some urine phthalate metabolites were negatively associated with TSH, TSHI, and TTSI levels and positively associated with FT3, T3, SPINA-GD, and SPINA-GT levels. None of the urine phthalate metabolites exhibited a significant association with thyroid autoimmunity. The associations of phthalate metabolites with thyroid function and thyroid homeostasis parameters differed based on thyroid autoantibody and metformin treatment status. Conclusions. Urinary phthalate metabolites may be associated with thyroid function and thyroid homeostasis parameters among participants with type 2 diabetes. Furthermore, our present study suggested that thyroid autoantibody status and metformin treatment status are potential mediators of such associations.

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“…The HOMA-IR is an appropriate measure of insulin resistance in the development of type II diabetes [ 34 ]. DBP is also reported to have a strong influence on the synergism of action of a mixture of bisphenols A, S, and F, diethyl phthalate (DEP), and bisphenol A diglycidyl ether [ 35 ]. Therefore, the presence of DBP in the environment alongside other pollutants can augment the linear trend observed for fasting glucose and HOMA-IR ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Subacute Exposure of Dibutyl Phthalate on the Homeostatic Model Assessment, Thyroid Function, and Redox Status in Rats

Majeed

Yousaf

Tahir

et al. 2021

BioMed Research International

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Dibutyl phthalate is an endocrine disruptor used in a wide range of industrial and agriculture applications. The present study focuses on elucidating the effect of subacute exposure (4-weeks) of DBP on insulin and its sensitivity indexes, oxidative status, thyroid function, energy metabolites, serum biochemistry, and anthropometry in rats. A total of 64 rats were divided into 4 treatment groups as mg DBP/Kg body weight per day: (a) 0 mg/Kg (control), (b) 10 mg/Kg (DBP-10), (c) 50 mg/Kg (DBP-50), and (d) 100 mg/Kg (DBP-100). The rats in each treatment ( n = 16 ) were further divided into male ( n = 8 ) and female ( n = 8 ) rats for studying treatment and gender interactions. Intraperitoneal glucose tolerance test (IPGTT) was performed on the 21st day. Anthropometry, nutritional determinants, fasting plasma glucose, fasting plasma insulin, homeostatic model assessment (HOMA), thyroid hormones, energy metabolites, and oxidative status were studied during the experimental period. Two-way ANOVA was used to analyze the data ( p < 0.05 ). Tukey’s posthoc test was used for pair-wise comparisons. DBP increased body weight gain and feed efficiency in an inverted nonmonotonic U -shaped fashion. Hyperglycemia and increased blood glucose area under the curve were observed in DBP-100 at 120 minutes in IPGTT. The HOMA also showed a linear monotonic contrast. Thyroxin decreased significantly in the DBP-100 rats, whereas malondialdehyde, nonesterified fatty acids, and beta hydroxyl butyrate were increased with the DBP treatments. In conclusion, DBP could be attributed to the development of hyperglycemia and insulin resistance in rats. Further investigations into the lipid peroxidation pathways can improve our understanding of the mechanisms involved in metabolic disruption.

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Identification of synergistic and antagonistic actions of environmental pollutants: Bisphenols A, S and F in the presence of DEP, DBP, BADGE and BADGE·2HCl in three component mixtures

Cited by 24 publications

References 38 publications

Testicular dysgenesis syndrome and phthalate exposure: A review of literature

Testicular dysgenesis syndrome and phthalate exposure: A review of literature

Association of Phthalate Exposure with Thyroid Function and Thyroid Homeostasis Parameters in Type 2 Diabetes

Effects of Subacute Exposure of Dibutyl Phthalate on the Homeostatic Model Assessment, Thyroid Function, and Redox Status in Rats

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