Identification of Stem Cell-Like Cells in the Ovary

Dong, Myung Hoon; Kim, Yoon Young; Ku, Seung‐Yup

doi:10.1007/s13770-021-00424-2

Cited by 3 publications

(4 citation statements)

References 51 publications

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“…It has been postulated that OCT4 appears to be “the strongest” factor in promoting iPSC programming [ 50 ]. In the ovaries of some mammals, e.g., in humans and rodents, the presence of ovarian stem cell-like cells (OSCs) have been described that seem to generate new functional oocytes capable of producing fertile offspring after in vitro procedures ( Figure 3 ) [ 78 , 79 ]. The differentiation of OSCs into different stages of oogenesis can be followed up by labeling the OCT4 factor or the meiotic marker SCP3 with GFP [ 78 ].…”

Section: Implementations Of Stem Cells For Reproductive and Regenerat...mentioning

confidence: 99%

“…In the ovaries of some mammals, e.g., in humans and rodents, the presence of ovarian stem cell-like cells (OSCs) have been described that seem to generate new functional oocytes capable of producing fertile offspring after in vitro procedures ( Figure 3 ) [ 78 , 79 ]. The differentiation of OSCs into different stages of oogenesis can be followed up by labeling the OCT4 factor or the meiotic marker SCP3 with GFP [ 78 ]. However, in addition to the data on humans and rodents that are taken into consideration for research on OSCs, data on bovine oocytes have also been provided in which the pluripotency markers OCT4 and SOX2 have been detected [ 78 , 80 ].…”

Section: Implementations Of Stem Cells For Reproductive and Regenerat...mentioning

confidence: 99%

“…The differentiation of OSCs into different stages of oogenesis can be followed up by labeling the OCT4 factor or the meiotic marker SCP3 with GFP [ 78 ]. However, in addition to the data on humans and rodents that are taken into consideration for research on OSCs, data on bovine oocytes have also been provided in which the pluripotency markers OCT4 and SOX2 have been detected [ 78 , 80 ]. Moreover, human ESCs can differentiate into OSCs and also into granulosa cells which, as mentioned above, are crucial for proper oocyte development.…”

Section: Implementations Of Stem Cells For Reproductive and Regenerat...mentioning

confidence: 99%

“…Depending on the type of material, various isolation methods are used, for instance, fluorescence-activated cell sorting (FACS), magnetic-activated cell sorting (MACS), immunocytochemistry, or anti-DDX4 antibody cell sorting, although most studies focus on FACS and MACS as isolation methods. Isolated ovarian stem cell-like cells from rabbits, monkeys, sheep, and menopausal women may form structures similar to oocytes or ESCs [ 78 ]. This may suggest that there is a chance for peri-menopausal or sub-fertile women to become pregnant [ 80 ].…”

Section: Implementations Of Stem Cells For Reproductive and Regenerat...mentioning

confidence: 99%

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Oogenesis in Women: From Molecular Regulatory Pathways and Maternal Age to Stem Cells

Krajnik

Miętkiewska

Skowrońska

et al. 2023

IJMS

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It is a well-known fact that the reproductive organs in women, especially oocytes, are exposed to numerous regulatory pathways and environmental stimuli. The maternal age is one cornerstone that influences the process of oocyte fertilization. More precisely, the longer a given oocyte is in the waiting-line to be ovulated from menarche to menopause, the longer the duration from oogenesis to fertilization, and therefore, the lower the chances of success to form a viable embryo. The age of menarche in girls ranges from 10 to 16 years, and the age of menopause in women ranges from approximately 45 to 55 years. Researchers are paying attention to the regulatory pathways that are impacting the oocyte at the very beginning during oogenesis in fetal life to discover genes and proteins that could be crucial for the oocyte’s lifespan. Due to the general trend in industrialized countries in the last three decades, women are giving birth to their first child in their thirties. Therefore, maternal age has become an important factor impacting oocytes developmental competence, since the higher a woman’s age, the higher the chances of miscarriage due to several causes, such as aneuploidy. Meiotic failures during oogenesis, such as, for instance, chromosome segregation failures or chromosomal non-disjunction, are influencing the latter-mentioned aging-related phenomenon too. These errors early in life of women can lead to sub- or infertility. It cannot be neglected that oogenesis is a precisely orchestrated process, during which the oogonia and primary oocytes are formed, and RNA synthesis takes place. These RNAs are crucial for oocyte growth and maturation. In this review, we intend to describe the relevance of regulatory pathways during the oogenesis in women. Furthermore, we focus on molecular pathways of oocyte developmental competence with regard to maternal effects during embryogenesis. On the background of transcriptional mechanisms that enable the transition from a silenced oocyte to a transcriptionally active embryo, we will briefly discuss the potential of induced pluripotent stem cells.

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Section: Implementations Of Stem Cells For Reproductive and Regenerat...mentioning

confidence: 99%

Section: Implementations Of Stem Cells For Reproductive and Regenerat...mentioning

confidence: 99%

Section: Implementations Of Stem Cells For Reproductive and Regenerat...mentioning

confidence: 99%

Section: Implementations Of Stem Cells For Reproductive and Regenerat...mentioning

confidence: 99%

See 2 more Smart Citations

Oogenesis in Women: From Molecular Regulatory Pathways and Maternal Age to Stem Cells

Krajnik

Miętkiewska

Skowrońska

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Transcriptomic Profiling of Reproductive Age Marmoset Monkey Ovaries

Kim,

Kim

et al. 2023

Reprod. Sci.

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Current Trends on Bioengineering Approaches for Ovarian Microenvironment Reconstruction

Almeida

Iglesia

Rinaldi

et al. 2023

Tissue Engineering Part B: Reviews

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Identification of Stem Cell-Like Cells in the Ovary

Cited by 3 publications

References 51 publications

Oogenesis in Women: From Molecular Regulatory Pathways and Maternal Age to Stem Cells

Oogenesis in Women: From Molecular Regulatory Pathways and Maternal Age to Stem Cells

Transcriptomic Profiling of Reproductive Age Marmoset Monkey Ovaries

Current Trends on Bioengineering Approaches for Ovarian Microenvironment Reconstruction

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