Identification of Ss protein as murine C4

Lachmann, P. J.; Grennan, Deidre; Martin, Angela; Démant, Peter

doi:10.1038/258242a0

Cited by 96 publications

(31 citation statements)

References 8 publications

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“…At all 10 positions in the murine C4 subunits that have been identified thus far, the same amino acids are present as are in the human C4 subunits. These results thus extend the strong evidence provided from a number of other studies (12)(13)(14)(15)(16)(17) that the Ss protein is the murine homologue of human C4.…”

supporting

confidence: 79%

Partial amino acid sequences of the murine fourth component of complement (C4): demonstration of homology with human C4 and identification of the amino-terminal subunit in pro-C4.

Parker¹,

Shreffler²,

Capra³

1980

Proc. Natl. Acad. Sci. U.S.A.

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supporting

confidence: 79%

Partial amino acid sequences of the murine fourth component of complement (C4): demonstration of homology with human C4 and identification of the amino-terminal subunit in pro-C4.

Parker¹,

Shreffler²,

Capra³

1980

Proc. Natl. Acad. Sci. U.S.A.

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“…Of the 13 propositi in whom no crossover was observed, meiosis was informative in only one parent and therefore a crossover is not ruled out in these children. An increase in intra-HLA recombinants has been observed in juvenile diabetes mellitus (42 (46)(47)(48). In addition, evidence has been presented that C3 level during ontogeny is MHC-linked in mouse (49).…”

Section: Discussionmentioning

confidence: 92%

The chromosomal order of genes controlling the major histocompatibility complex, properdin factor B, and deficiency of the second component of complement.

Raum¹,

Glass

Carpenter

et al. 1976

J. Clin. Invest.

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“…HcO (MuBIO), this gene being non H-2 linked) (Erickson et al, 1964;Cinader, Duhiski and Wardlaw, 1964). Thus, males, and often the females, of CBA/H, by beterologous antisera and this product is now believed to he C4 (Meo, Krasteff and Shreffler, 1975;Lachman et al, 1975).…”

mentioning

confidence: 99%

STUDIES ON IMMUNE RESPONSES TO LARVAL CESTODES IN MICE. INCREASED SUSCEPTIBILITY OF CERTAIN MOUSE STRAINS AND HYPOTHYMIC MICE TO TAENlA TAENIAEFORMIS AND ANALYSIS OF PASSIVE TRANSFER OF RESISTANCE WITH SERUM

Mitchell

Goding

Rickard

1977

Aust J Exp Biol Med

102

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Summary. Various inbred strains of mice vary markedly in their susceptibility to the larvae of the cestode, Toenia taeniaeformis. Males are generally more snsceptible than females and the most susceptible common inbred mouse strains are those which are deficient in C5 and/or C4 components of complement. However, no genetic evidence is yet available to implicate loci controlling complement levels in susceptihility/resistance, and multiple genetic factors appear to be operative. Hypothymic, nu/nu ("nude") mice of tlie relatively resistant mouse strain, BALB/c, are highly susceptible in that cystic larvae in the liver develop in large numbers and more rapidly than in intact BALB/c.nu/+ littermates. Cyclophosphamide pretreatment also . increases tlie susceptibility of relatively resistant strains of mice in terms of both the number and size of liver cysts. Hypothymic and intact mice can be protected, absolutely, by an injection of serum from infected intact mice, provided the serum is given to recipient mice close to the time of oral egg administration. The protective activity of immune serum is absorbed totally by staphylococcal protein A-Sepharose columns and can be abolished by treahneut of recipients with cobra venom factor. Cyst fluid from established larvae facilitates the activity of subhaemolytic amounts of guinea pig complement in a standard direct PFC assay. The data suggest that complement-fixing antibodies are responsible for inhibition of establishing larvae in mice and that one method of protection for established cystic larvae involves the alteration of host complement activity within the cyst.

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Identification of Ss protein as murine C4

Cited by 96 publications

References 8 publications

Partial amino acid sequences of the murine fourth component of complement (C4): demonstration of homology with human C4 and identification of the amino-terminal subunit in pro-C4.

Partial amino acid sequences of the murine fourth component of complement (C4): demonstration of homology with human C4 and identification of the amino-terminal subunit in pro-C4.

The chromosomal order of genes controlling the major histocompatibility complex, properdin factor B, and deficiency of the second component of complement.

STUDIES ON IMMUNE RESPONSES TO LARVAL CESTODES IN MICE. INCREASED SUSCEPTIBILITY OF CERTAIN MOUSE STRAINS AND HYPOTHYMIC MICE TO TAENlA TAENIAEFORMIS AND ANALYSIS OF PASSIVE TRANSFER OF RESISTANCE WITH SERUM

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