Identification of specificityH-2.7 as an erythrocyte antigen: Control by an independent locus,H-2G, between theS andD regions

Abstract

Specificity H-2.7 is expressed predominantly on erythrocytes and controlled by a gene that maps within the H-2 gene complex at a locus, designated as H-2G, which apparently lies between regions S and D.

Specificity in T Cell Mediated Lympholysis: Identical Genetic Control of the Proliferative and Effector Phases of Allogeneic and Xenogeneic Reactions

“…Schematic representation of the H-2 region, its products, and associated biological functions. A current view of the genetic map of the H-2 region, based on David et al (1975), Klein (1975) and Lindahl et al (1976) is presented showing a graphical idea of the H-2 SD Petersson et al (1975) and Ia antigens. The simplexcomplex interpretation of the H-2 charts suggests the H-2 SD molecules are glycoproteins carrying several different antigenic detenninants, some unique to a given allele (private specificities) and others associated with two or more alleles (puhlic specificities).…”

Genetic and Functional Analysis of the Ia Antigens: Their Possible Role in Regulating the Immune Response

“…This interpretation is identical to that of Shreffler & David (1975), with one exception. Recently, a new region, designated G, has been localized between the 5 and D regions (David et al 1975d. A gene in this segment, H-2G, controls determinants which are found predominantly on erythrocytes.…”

Mixed Lymphocyte Reactivity and Cell‐Mediated Lympholysis to D‐End Differences of the Murine Major Histocompatibility Complex

“…From such studies it is evident that the D region may itself represent a functionally complex genetic region that may eventually bf subdivided into genetic domains controlling several parameters of immune response (analogous to the I region) and a complex of serologically determined histocompatibilit)' antigens. The roie of the recently described G region (4,13) in MLC and CML reactivity is not yet clear. There is no G-region difference between BI0.D2 and BlO.D2(M5O4), so reactivities between these strains are not due to G differences.…”