Identification of sorbitol esterification of glutamic acid by LC-MS/MS in a monoclonal antibody stability assessment
Bin Yu,
Shannon Williams,
Zhengdong Yang
et al.
Abstract:The stability of monoclonal antibodies (mAbs) is vital for their therapeutic success. Sorbitol, a common mAb stabilizer used to prevent aggregation, was evaluated for any potential adverse effects on the chemical stability of mAb X. An LC-MS/MS based analysis focusing on the post-translational modifications (PTMs) of mAb X was conducted on samples that had undergone accelerated aging at 40°C. Along with PTMs that are known to affect mAbs’ structure function and stability (such as deamidation and oxidation), a … Show more
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