Identification of Somatosensory Pathways by Focal-Cooling-Induced Changes of Somatosensory Evoked Potentials and EEG-Activity - an Experimental Study

Schwerdtfeger, Karsten; Tiling, S von; Kiefer, M.; Strowitzkí, Martin; Mestres, Pedro; Booz, K. H.; Steudel, W. I.

doi:10.1007/s007010050355

Cited by 11 publications

(10 citation statements)

References 30 publications

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“…Previous electrophysiological studies have revealed that temperature changes can also modulate neural activity (Bindman et al, 1963;Moseley et al, 1972;Moser et al, 1993;Sabatini and Regehr, 1996;Hupé et al, 1998;Schwerdtfeger et al, 1999;Aihara et al, 2001;Long and Fee, 2008;Stujenske et al, 2015;Ait Ouares et al, 2019;Owen et al, 2019). However, how this modulation occurs remains controversial.…”

Section: Introductionmentioning

confidence: 99%

“…It has also been reported that, during an epilepsy episode, cooling the brain could cease hyperactivity in human patients (Ommaya and Baldwin, 1963;Karkar et al, 2002;Nomura et al, 2014), as well as in animals (Motamedi et al, 2006;Inoue et al, 2017). Other studies have reported contradictory findings, i.e., that cooling the brain increases neural activity (or that heating the brain decreases neural activity; Bindman et al, 1963;Moser et al, 1993;Schwerdtfeger et al, 1999;Ait Ouares et al, 2019;Owen et al, 2019). More importantly, little is known about the effects of temperature on brain information processing at the network level, where multiple inputs of different neurotransmitters are integrated (e.g., glutamate, GABA, dopamine, et cetera).…”

Section: Introductionmentioning

confidence: 99%

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Brain Temperature Alters Contributions of Excitatory and Inhibitory Inputs to Evoked Field Potentials in the Rat Frontal Cortex

Gotoh

Nagasaka

Nakata

et al. 2020

Front. Cell. Neurosci.

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Changes in brain temperature have been reported to affect various brain functions. However, little is known about the effects of temperature on the neural activity at the network level, where multiple inputs are integrated. In this study, we recorded cortical evoked potentials while altering the local brain temperature in anesthetized rats. We delivered electrical stimulations to the midbrain dopamine area and measured the evoked potentials in the frontal cortex, the temperature of which was locally altered using a thermal control device. We focused on the maximum negative peaks, which was presumed to result mainly from polysynaptic responses, to examine the effect of local temperature on network activity. We showed that focal cortical cooling increased the amplitude of evoked potentials (negative correlation, >17°C); further cooling decreased their amplitude. This relationship would be graphically represented as an inverted-U-shaped curve. The pharmacological blockade of GABAergic inhibitory inputs eliminated the negative correlation (>17°C) and even showed a positive correlation when the concentration of GABAA receptor antagonist was sufficiently high. Blocking the glutamatergic excitatory inputs decreased the amplitude but did not cause such inversion. Our results suggest that the negative correlation between the amplitude of evoked potentials and the near-physiological local temperature is caused by the alteration of the balance of contribution between excitatory and inhibitory inputs to the evoked potentials, possibly due to higher temperature sensitivity of inhibitory inputs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brain Temperature Alters Contributions of Excitatory and Inhibitory Inputs to Evoked Field Potentials in the Rat Frontal Cortex

Gotoh

Nagasaka

Nakata

et al. 2020

Front. Cell. Neurosci.

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“…16) Focal cooling of the somatosensory cortex in rats by 209 C for 5 minutes induces recognizable changes of the somatosensory evoked potential, which are fully reversible after warming up the tissue. 25) These studies suggest that reversible neurophysiological dysfunctions are induced at a threshold temperature of approximately 209 C.…”

Section: Influence Of Focal Cooling On Neurophysiological Functionsmentioning

confidence: 97%

Application of Focal Cerebral Cooling for the Treatment of Intractable Epilepsy

Fujii

Fujioka

Oku

et al. 2010

Neurol. Med. Chir.(Tokyo)

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Epilepsy is usually treated with medication, but adequate seizure control is still not achieved in over 30% of epilepsy patients, even with the best available agents. Surgical treatment is also performed for such patients, but is not always successful. Focal cooling of the brain using a thermoelectric device has recently been evaluated as an alternative to epilepsy surgery. Brain cooling was first proposed approximately 50 years ago as an effective method for suppressing epileptic discharges (EDs). Recent studies indicate that focal cooling of the brain to a cortical surface temperature of 209 C to 259 C terminates EDs without inducing irreversible neurophysiological dysfunctions or neuronal damage in the brain tissue. Several mechanisms have been proposed for the antiepileptic effects of focal cooling, including reduction in neurotransmitter release, alternation of activation-inactivation kinetics in voltage-gated ion channels, and the slowing of catabolic processes. Developments in the implantable cooling device with closed-loop cooling systems for seizure detection and focal cooling have been promoted in the field of neuromodulation, but several aspects remain uncharacterized concerning the hardware. Recent advances in precision devices have enabled the optimization of the implantable local cooling system, which may become clinically applicable in the near future.

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“…Cooling has been shown to suppress reversibly normal central nervous system activity (4)(5)(6)(7)(8)(9)(10)(11)(12). Several in vitro and in vivo studies have demonstrated that focal brain cooling also reduces epileptiform activity in seizure models (13)(14)(15)(16)(17)(18) and in humans (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Transcortical Cooling Inhibits Hippocampal‐kindled Seizures in the Rat

et al. 2005

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Summary:Purpose: When epileptogenic regions encroach on eloquent brain, surgery may incur unacceptable deficits. Reversible cooling may control seizures while preserving function. We describe the effects of cooling kindled seizures in awake, freely moving rats.Methods: We kindled rats after placement of a bipolar electrode and a copper cooling coil in dorsal hippocampus. Fully kindled animals (three consecutive grade 5 seizures) were cooled to one of two target temperatures (24• or 27• C) for 3 min preceding a kindling stimulation and 2 minutes after. We compared seizure score (0-5) and afterdischarge duration (ADD) with and without cooling. Target temperatures were confirmed in identical animals by using a needle thermocouple advanced to the kindling target while circulating coolant.Results: Circulation of 16 • C and 8• C coolant reliably achieved transcortical cooling of the hippocampal target to 27.0 ± 1.2• C and 23.8 ± 2.0• C, respectively, by 180 s. Cooling with 16• C coolant (n = 5) significantly reduced seizure scores from 5 to 2.57 ± 1.56, and ADD from 142 ± 94.5 s to 45.7 ± 20.5 s.Cooling with 8• C coolant (n = 5) reduced seizure scores from 5 to 2.0 ± 0.42, and ADD from 132.3 ± 29.6 s to 55.5 ± 25.9 s. In 33.3% of all cooled stimulations, grade 0 seizures resulted; grade 5 seizures recurred during subsequent stimulations when cooling was withheld.Conclusions: Fully kindled, tonic-clonic seizures can be suppressed or aborted with periictal cooling of the kindling target. Anticonvulsant activity occurred at temperatures well above those known to result in tissue injury or inhibition of normal neurologic function. These findings have important implications for the potential use of implantable cooling devices in humans with refractory epilepsies in or near eloquent cortex or dominant hippocampal formations.

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Identification of Somatosensory Pathways by Focal-Cooling-Induced Changes of Somatosensory Evoked Potentials and EEG-Activity - an Experimental Study

Cited by 11 publications

References 30 publications

Brain Temperature Alters Contributions of Excitatory and Inhibitory Inputs to Evoked Field Potentials in the Rat Frontal Cortex

Brain Temperature Alters Contributions of Excitatory and Inhibitory Inputs to Evoked Field Potentials in the Rat Frontal Cortex

Application of Focal Cerebral Cooling for the Treatment of Intractable Epilepsy

Transcortical Cooling Inhibits Hippocampal‐kindled Seizures in the Rat

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